来自鼻疽伯克霍尔德菌和泰国伯克霍尔德菌的肌动蛋白结合蛋白可在功能上弥补类鼻疽伯克霍尔德菌bimA突变体基于肌动蛋白的运动缺陷。
Actin-binding proteins from Burkholderia mallei and Burkholderia thailandensis can functionally compensate for the actin-based motility defect of a Burkholderia pseudomallei bimA mutant.
作者信息
Stevens Joanne M, Ulrich Ricky L, Taylor Lowrie A, Wood Michael W, Deshazer David, Stevens Mark P, Galyov Edouard E
机构信息
Division of Microbiology, Institute for Animal Health, Compton Laboratory, Berkshire, UK.
出版信息
J Bacteriol. 2005 Nov;187(22):7857-62. doi: 10.1128/JB.187.22.7857-7862.2005.
Abstract
Recently we identified a bacterial factor (BimA) required for actin-based motility of Burkholderia pseudomallei. Here we report that Burkholderia mallei and Burkholderia thailandensis are capable of actin-based motility in J774.2 cells and that BimA homologs of these bacteria can restore the actin-based motility defect of a B. pseudomallei bimA mutant. While the BimA homologs differ in their amino-terminal sequence, they interact directly with actin in vitro and vary in their ability to bind Arp3.
摘要
最近，我们鉴定出了一种与类鼻疽伯克霍尔德菌基于肌动蛋白的运动性所需的细菌因子（BimA）。在此，我们报告，鼻疽伯克霍尔德菌和泰国伯克霍尔德菌能够在J774.2细胞中进行基于肌动蛋白的运动，并且这些细菌的BimA同源物可以恢复类鼻疽伯克霍尔德菌bimA突变体基于肌动蛋白的运动缺陷。虽然BimA同源物在其氨基末端序列上有所不同，但它们在体外直接与肌动蛋白相互作用，并且在结合Arp3的能力上有所差异。
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