Toll样受体和白细胞介素-1受体家族的配体对细胞的激活作用取决于人类巨噬细胞中大电导钾通道MaxiK的功能。
Cell activation by ligands of the toll-like receptor and interleukin-1 receptor family depends on the function of the large-conductance potassium channel MaxiK in human macrophages.
作者信息
Scheel Olaf, Papavlassopoulos Martin, Blunck Rikard, Gebert Andreas, Hartung Thomas, Zähringer Ulrich, Seydel Ulrich, Schromm Andra B
机构信息
Research Center Borstel, Department of Immunochemistry and Biochemical Microbiology, Division of Biophysics, Parkallee 10, 23845 Borstel, Germany.
出版信息
Infect Immun. 2006 Jul;74(7):4354-6. doi: 10.1128/IAI.01783-05.
Abstract
Performing patch-clamp experiments on human macrophages, we show that the K(+) channel MaxiK is activated by lipopolysaccharide, peptidoglycan, and interleukin-1. Cytokine production initiated by several Toll-like receptor (TLR) ligands and by interleukin-1 is inhibited by MaxiK blockade. This provides evidence for functional association of the MaxiK channel and TLR signaling complexes.
摘要
在对人类巨噬细胞进行膜片钳实验时，我们发现大电导钙激活钾通道（MaxiK）可被脂多糖、肽聚糖和白细胞介素-1激活。由几种Toll样受体（TLR）配体和白细胞介素-1引发的细胞因子产生会被MaxiK阻断所抑制。这为MaxiK通道与TLR信号复合物之间的功能关联提供了证据。
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本文引用的文献
1
Toll-like receptor signalling.
Nat Rev Immunol. 2004 Jul;4(7):499-511. doi: 10.1038/nri1391.
2
Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2: higher affinity than that with MD-2 or CD14.
J Exp Med. 2003 Oct 6;198(7):1035-42. doi: 10.1084/jem.20031076. Epub 2003 Sep 29.
3
The immunopathogenesis of sepsis.
Nature. 2002;420(6917):885-91. doi: 10.1038/nature01326.
4
A K+ channel is involved in LPS signaling.
J Endotoxin Res. 2001;7(3):243-7.
5
Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling.
J Exp Med. 2001 Jul 2;194(1):79-88. doi: 10.1084/jem.194.1.79.
6
Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2.
J Biol Chem. 2001 Jun 15;276(24):21129-35. doi: 10.1074/jbc.M009164200. Epub 2001 Mar 26.
7
Structure-function relationship of cytokine induction by lipoteichoic acid from Staphylococcus aureus.
J Exp Med. 2001 Feb 5;193(3):393-7. doi: 10.1084/jem.193.3.393.
8
New insights into endotoxin-induced activation of macrophages: involvement of a K+ channel in transmembrane signaling.
J Immunol. 2001 Jan 15;166(2):1009-15. doi: 10.4049/jimmunol.166.2.1009.
9
Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.
Immunity. 1999 Oct;11(4):443-51. doi: 10.1016/s1074-7613(00)80119-3.
10
MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4.
J Exp Med. 1999 Jun 7;189(11):1777-82. doi: 10.1084/jem.189.11.1777.
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