Marion Rachel, Baishanbo Asiya, Gargala Gilles, François Arnaud, Ducrotté Philippe, Duclos Celia, Fioramonti Jean, Ballet Jean Jacques, Favennec Loïc
Laboratoire de Parasitologie and ADEN UPRES EA-3234, CHU Charles-Nicolle, 1, rue de Germont, 76031 Rouen, France.
Infect Immun. 2006 Jul;74(7):4387-9. doi: 10.1128/IAI.02055-05.
In 5-day-old immunocompetent Sprague-Dawley rats infected with either 10(2) or 10(5) Cryptosporidium parvum oocysts, transient infection resulted 120 days later in increased cardiovascular depressor response to jejunal distension and jejunal myeloperoxidase activity (P < 0.05). Nitazoxanide treatment normalized jejunal sensitivity (P < 0.001) but not myeloperoxidase levels (P > 0.05). Data warrant further evaluation of the role of early cryptosporidiosis in the development of chronic inflammatory gut conditions.
在感染了10²或10⁵个微小隐孢子虫卵囊的5日龄免疫功能正常的斯普拉格-道利大鼠中,120天后短暂感染导致对空肠扩张的心血管降压反应增强以及空肠髓过氧化物酶活性增加(P < 0.05)。硝唑尼特治疗使空肠敏感性恢复正常(P < 0.001),但髓过氧化物酶水平未恢复正常(P > 0.05)。这些数据值得进一步评估早期隐孢子虫病在慢性炎症性肠道疾病发展中的作用。