Bortfeld Thomas
Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Phys Med Biol. 2006 Jul 7;51(13):R363-79. doi: 10.1088/0031-9155/51/13/R21. Epub 2006 Jun 20.
The very first cornerstone paper on intensity-modulated radiation therapy (IMRT) was published in Physics in Medicine and Biology, and many seminal IMRT works have since appeared in this journal. Today IMRT is a widely used clinical treatment modality in many countries. This contribution to the 50th anniversary issue reviews the physical, mathematical, and technological milestones that have facilitated the clinical implementation and success of IMRT. In particular, the basic concepts and developments of both IMRT treatment planning ('inverse planning') and the delivery of cone-beam IMRT with a multileaf collimator from a fixed number of static beam directions are discussed. An outlook into the future of IMRT concludes the paper.
关于调强放射治疗（IMRT）的第一篇基石性论文发表在《物理医学与生物学》上，此后该期刊上出现了许多IMRT的开创性作品。如今，IMRT在许多国家都是一种广泛使用的临床治疗方式。这篇为纪念创刊50周年而撰写的文章回顾了推动IMRT临床应用和成功的物理、数学和技术里程碑。特别讨论了IMRT治疗计划（“逆向计划”）的基本概念和发展，以及从固定数量的静态射野方向使用多叶准直器进行锥形束IMRT的实现。文章最后展望了IMRT的未来。
