Webb S
Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey SM2 5PT, UK.
Phys Med Biol. 2006 Jul 7;51(13):R403-25. doi: 10.1088/0031-9155/51/13/R23. Epub 2006 Jun 20.
During a course of fractionated radiation therapy and between the fractions the tissues of the human body may move relative to some reference location in which the radiation therapy was planned. This has been known for over a century and simple 'coping mechanisms' (margins) have been used to approximately compensate. Since the introduction of highly accurate conformal radiation therapy and intensity-modulated radiation therapy (IMRT) attention has focused strongly in the last few years on understanding and compensating more appropriately for these motions. Thus, unlike most of the reviews in this special 50th anniversary issue which look back over decades of development, this one looks back at most within just the past decade and reviews the current situation. There is still much more work to be done and many of the techniques reviewed are themselves not yet implemented widely in the clinic.
在分次放射治疗过程中以及分次之间，人体组织可能会相对于放射治疗计划所依据的某个参考位置发生移动。这一情况已为人所知达一个多世纪，人们一直采用简单的“应对机制”（边界）来进行大致补偿。自从高精度适形放射治疗和调强放射治疗（IMRT）问世以来，在过去几年里，人们的注意力高度集中于更恰当地理解和补偿这些运动。因此，与本期第50周年特刊中的大多数回顾文章回顾几十年的发展历程不同，本文最多回顾过去十年的情况并审视当前现状。仍有大量工作要做，而且所回顾的许多技术本身在临床上尚未得到广泛应用。
