Sanchez Justin C, Alba Nicolas, Nishida Toshikazu, Batich Christopher, Carney Paul R
Department of Pediatrics, Division of Neurology, University of Florida, Gainesville, FL 32611, USA.
IEEE Trans Neural Syst Rehabil Eng. 2006 Jun;14(2):217-21. doi: 10.1109/TNSRE.2006.875581.
Long-term viability of chronic invasive neural probes is a necessary condition for extracting robust control signals directly from neural tissue. Although immune/tissue response is a leading factor in the degradation of single neuron recording, we investigate a second component of signal degradation connected to the structural changes associated with microwire electrodes chronically exposed to extracelluar environments in vivo. Scanning electron microscopy is used to assess the surface modifications to the electrodes after an implantation duration of four weeks in rats. The electrode developed a smooth fracture surface, a reduction of the metal diameter, and pitting in the insulation of the electrode structure. Over the duration of implantation, recording properties of the electrode were marked by a reduction in the peak-to-peak amplitude in neuronal firing.
慢性侵入性神经探针的长期存活能力是直接从神经组织中提取稳定控制信号的必要条件。尽管免疫/组织反应是单神经元记录退化的主要因素，但我们研究了信号退化的第二个组成部分，它与微丝电极在体内长期暴露于细胞外环境相关的结构变化有关。使用扫描电子显微镜评估大鼠植入四周后电极的表面变化。电极出现了光滑的断裂表面、金属直径减小以及电极结构绝缘层中的点蚀。在植入期间，电极的记录特性表现为神经元放电峰峰值幅度降低。
