Kipke Daryl R, Vetter Rio J, Williams Justin C, Hetke Jamille F
Department of Biomedical Engineering, the University of Michigan, Ann Arbor 48109-2099, USA.
IEEE Trans Neural Syst Rehabil Eng. 2003 Jun;11(2):151-5. doi: 10.1109/TNSRE.2003.814443.
This study investigated the use of planar, silicon-substrate microelectrodes for chronic unit recording in the cerebral cortex. The 16-channel microelectrodes consisted of four penetrating shanks with four recording sites on each shank. The chronic electrode assembly included an integrated silicon ribbon cable and percutaneous connector. In a consecutive series of six rats, 5/6 (83%) of the implanted microelectrodes recorded neuronal spike activity for more than six weeks, with four of the implants (66%) remaining functional for more than 28 weeks. In each animal, more than 80% of the electrode sites recorded spike activity over sequential recording sessions during the postoperative time period. These results provide a performance baseline to support further electrode system development for intracortical neural implant systems for medical applications.
本研究调查了用于大脑皮层慢性单位记录的平面硅基微电极的使用情况。16通道微电极由四个穿透杆组成，每个杆上有四个记录位点。慢性电极组件包括集成的硅带状电缆和经皮连接器。在连续的六只大鼠系列中，5/6（83%）的植入微电极记录神经元尖峰活动超过六周，其中四个植入物（66%）在超过28周的时间内仍保持功能。在每只动物中，超过80%的电极位点在术后时间段的连续记录过程中记录到尖峰活动。这些结果提供了一个性能基线，以支持用于医疗应用的皮质内神经植入系统的进一步电极系统开发。
