来自海洋真菌秀丽针孢菌的10-苯基-[12]-细胞松弛素Z7、Z8和Z9。

10-Phenyl-[12]-cytochalasins Z7, Z8, and Z9 from the marine-derived fungus Spicaria elegans.

作者信息

Liu Rui, Gu Qianqun, Zhu Weiming, Cui Chengbin, Fan Guotao, Fang Yuchun, Zhu Tianjiao, Liu Hongbing

机构信息

Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China, Qingdao 266003, People's Republic of China.

出版信息

J Nat Prod. 2006 Jun;69(6):871-5. doi: 10.1021/np050201m.

DOI:10.1021/np050201m

PMID:16792402

Abstract

The three new 10-phenyl-[12]-cytochalasins Z7, Z8, and Z9 (1-3), together with two known analogues, cytochalasins E (4) and K (5), were isolated from the marine-derived fungus Spicaria elegans. This is only the second report to date that cytochalasins contain a 12-membered macrocyclic ring. The structures of the three new cytochalasins were elucidated by spectroscopic methods, and their absolute configurations were determined for the first time by the modified Mosher's method. All five cytochalasins were evaluated for their cytotoxic effects on P388 and A-549 cell lines by the MTT method.

摘要

从海洋来源的真菌秀丽针孢菌中分离出三种新的10-苯基-[12]-细胞松弛素Z7、Z8和Z9（1-3），以及两种已知类似物细胞松弛素E（4）和K（5）。这是迄今为止关于细胞松弛素含有12元大环的第二篇报道。通过光谱方法阐明了三种新细胞松弛素的结构，并首次通过改良的莫舍尔方法确定了它们的绝对构型。采用MTT法评估了所有五种细胞松弛素对P388和A-549细胞系的细胞毒性作用。