曲霉毒素I、J和K：来自索诺兰沙漠拉瑞松叶菊根际的黄曲霉菌产生的三种新型细胞毒性细胞松弛素。

Aspochalasins I, J, and K: three new cytotoxic cytochalasans of Aspergillus flavipes from the rhizosphere of Ericameria laricifolia of the Sonoran Desert.

作者信息

Zhou Guang-Xiong, Wijeratne E M Kithsiri, Bigelow Donna, Pierson Leland S, VanEtten Hans D, Gunatilaka A A Leslie

机构信息

SW Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, University of Arizona, 250 E. Valencia Road, Tucson, Arizona 85706-6800, USA.

出版信息

J Nat Prod. 2004 Mar;67(3):328-32. doi: 10.1021/np030353m.

DOI:10.1021/np030353m

PMID:15043404

Abstract

Bioassay-guided fractionation of a cytotoxic EtOAc extract of Aspergillus flavipes occurring in the rhizosphere of Ericameria laricifolia resulted in the isolation of three new cytochalasans, namely, aspochalasins I (1), J (2), and K (3), and four known cytochalasans, aspochalasins C (4), D (5), and E (6) and TMC-169 (7). The structures of compounds 1-3 were established on the basis of extensive 1D and 2D NMR spectroscopic analysis. All compounds exhibited weak to moderate cytotoxicity against NCI-H460, MCF-7, and SF-268 cancer cell lines, but none showed significant selectivity.

摘要

对生长在柳叶蒿艾根际的黄曲霉菌细胞毒性乙酸乙酯提取物进行生物测定导向的分级分离，得到了三种新的细胞松弛素，即曲霉松弛素I（1）、J（2）和K（3），以及四种已知的细胞松弛素，曲霉松弛素C（4）、D（5）和E（6）以及TMC-169（7）。化合物1-3的结构是基于广泛的一维和二维核磁共振光谱分析确定的。所有化合物对NCI-H460、MCF-7和SF-268癌细胞系均表现出弱至中度的细胞毒性，但均未表现出明显的选择性。