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柄壳孢菌素A-D，四种源自湿地真菌的新细胞松弛素。

Pycnidiophorones A-D, four new cytochalasans from the wetland derived fungus .

作者信息

Zhao Chen, Liu Gaoran, Liu Xingzhong, Zhang Lan, Li Lin, Liu Ling

机构信息

Department of Pharmacy, Xuanwu Hospital of Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing Engineering Research Center for Nervous System Drugs, Beijing Institute for Brain Disorders, Key Laboratory for Neurodegenerative Diseases of Ministry of Education Beijing 100053 China

State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences Beijing 100101 People's Republic of China

出版信息

RSC Adv. 2020 Nov 5;10(66):40384-40390. doi: 10.1039/d0ra08072a. eCollection 2020 Nov 2.

DOI:10.1039/d0ra08072a
PMID:35520825
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9057502/
Abstract

Pycnidiophorones A-D (1-4), four new cytochalasans with a rare 5/6/6/5/6 pentacyclic skeleton incorporating the unique 12-oxatricyclo[6.3.1.0]dodecane core, and six known depsidones (5-10) were isolated from cultures of the wetland-soil-derived fungus . Their chemical structures were unambiguously determined using NMR spectroscopic data. The absolute configurations of 1 and 3 were assigned by electronic circular dichroism (ECD) calculations. Compounds 1-10 showed moderate cytotoxicity against a panel of five human tumor cell lines.

摘要

从湿地土壤来源的真菌培养物中分离得到了Pycnidiophorones A-D（1-4），这是四种具有罕见的5/6/6/5/6五环骨架并包含独特的12-氧杂三环[6.3.1.0]十二烷核心的新细胞松弛素，以及六种已知的缩酚酸环醚（5-10）。利用核磁共振光谱数据明确确定了它们的化学结构。通过电子圆二色性（ECD）计算确定了1和3的绝对构型。化合物1-10对一组五种人类肿瘤细胞系显示出中等程度的细胞毒性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/144c/9057502/7a2ecccba563/d0ra08072a-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/144c/9057502/76e6a8616619/d0ra08072a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/144c/9057502/1aa95a463d0e/d0ra08072a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/144c/9057502/502c90802204/d0ra08072a-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/144c/9057502/b810aedfe1ff/d0ra08072a-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/144c/9057502/7a2ecccba563/d0ra08072a-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/144c/9057502/76e6a8616619/d0ra08072a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/144c/9057502/1aa95a463d0e/d0ra08072a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/144c/9057502/502c90802204/d0ra08072a-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/144c/9057502/b810aedfe1ff/d0ra08072a-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/144c/9057502/7a2ecccba563/d0ra08072a-f5.jpg

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