Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Huazhong University of Science and Technology, Hangkong Road 13#, Wuhan, 430030, People's Republic of China.
Prog Chem Org Nat Prod. 2021;114:1-134. doi: 10.1007/978-3-030-59444-2_1.
Cytochalasans are a group of fungal-derived natural products characterized by a perhydro-isoindolone core fused with a macrocyclic ring, and they exhibit a high structural diversity and a broad spectrum of bioactivities. Cytochalasans have attracted significant attention from the chemical and pharmacological communities and have been reviewed previously from various perspectives in recent years. However, continued interest in the cytochalasans and the number of laboratory investigations on these compounds are both growing rapidly. This contribution provides a general overview of the isolation, structural determination, biological activities, biosynthesis, and total synthesis of cytochalasans. In total, 477 cytochalasans are covered, including "merocytochalasans" that arise by the dimerization or polymerization of one or more cytochalasan molecules with one or more other natural product units. This contribution provides a comprehensive treatment of the cytochalasans, and it is hoped that it may stimulate further work on these interesting natural products.
细胞松弛素是一组真菌来源的天然产物，其特征为具有与大环环稠合的全氢异吲哚酮核心，具有高度的结构多样性和广泛的生物活性。细胞松弛素引起了化学和药理学领域的极大关注，并在近年来从不同角度进行了综述。然而，人们对细胞松弛素的持续关注以及对这些化合物的实验室研究数量都在迅速增加。本综述概述了细胞松弛素的分离、结构确定、生物活性、生物合成和全合成。共涵盖了 477 种细胞松弛素，包括“单环细胞松弛素”，它是由一个或多个细胞松弛素分子与一个或多个其他天然产物单元的二聚化或聚合产生的。本综述对细胞松弛素进行了全面的综述，希望能激发对这些有趣的天然产物的进一步研究。
