从卷枝毛壳菌 TY1 中分离得到细胞毒性吖嗪菲酮生物碱。
Cytotoxic azaphilone alkaloids from Chaetomium globosum TY1.
机构信息
College of Plant Sciences, Jilin University, Changchun, 130062 Jilin, China.
出版信息
Bioorg Med Chem Lett. 2013 May 15;23(10):2945-7. doi: 10.1016/j.bmcl.2013.03.044. Epub 2013 Mar 21.
Three novel azaphilone alkaloids, namely chaetomugilides A-C (1-3), together with three related compounds (4-6) were isolated from the methanol extract of Chaetomium globosum TY1, an endophytic fungus isolated from Ginkgo biloba. Their structures were elucidated on the basis of extensive 1D and 2D NMR as well as HRESI-MS spectroscopic data analysis. The isolated compounds exhibited highly cytotoxic activities against human cancer cell line HePG2 with the IC50 values range from 1.7 to 53.4μM.
从银杏内生真菌卷边毛壳菌 TY1 的甲醇提取物中分离得到 3 种新型的氮杂菲酮生物碱，即 chaetomugilides A-C（1-3），以及 3 种相关化合物（4-6）。根据 1D 和 2D NMR 以及 HRESI-MS 光谱数据分析，确定了它们的结构。分离得到的化合物对人肝癌细胞系 HePG2 表现出较强的细胞毒性，IC50 值范围为 1.7-53.4μM。
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