Maldonado-Codina Carole, Efron Nathan
Eurolens Research, Faculty of Life Sciences, The University of Manchester, Manchester, UK.
Ophthalmic Physiol Opt. 2006 Jul;26(4):408-18. doi: 10.1111/j.1475-1313.2006.00394.x.
Standard methods of contact angle analysis include sessile drop, captive bubble and Wilhelmy plate techniques; however, these methodologies are not particularly well suited for assessing the wettability of the surfaces of formed hydrogel contact lenses. This paper describes two methodologies that are adaptations of previously described techniques. The maximum adherent force method is an adaptation of the dynamic Wilhelmy plate technique that allows the assessment of whole, finished contact lenses. The dynamic photographic method allows the simultaneous assessment of the front and back surfaces of strip samples for the assessment of advancing and receding contact angles. Lenses investigated were made from polyhydroxyethyl methacrylate, hydroxyethyl methacrylate/methacrylic acid and hydroxyethyl methacrylate/glycerol methacrylate. The lenses were manufactured by lathing, spin-casting or cast-moulding techniques. Overall, both techniques demonstrated few differences between the wettability of different lens materials and no differences between materials of the 'same' lens type but manufactured by different methods. These findings are consistent with the results of clinical studies, which have shown little difference between contact lens surface wettability in vivo, which may be due to the apparent natural surface wettability-enhancing properties of the pre-lens tear film.
接触角分析的标准方法包括静滴法、俘获气泡法和威尔海姆平板技术；然而，这些方法并不特别适合评估成型水凝胶隐形眼镜表面的润湿性。本文描述了两种对先前所述技术进行改进的方法。最大附着力法是对动态威尔海姆平板技术的改进，可用于评估完整的成品隐形眼镜。动态摄影法可同时评估条状样品的前后表面，以测定前进接触角和后退接触角。所研究的隐形眼镜由聚甲基丙烯酸羟乙酯、甲基丙烯酸羟乙酯/甲基丙烯酸和甲基丙烯酸羟乙酯/甲基丙烯酸甘油酯制成。这些隐形眼镜通过车削、旋铸或铸模技术制造。总体而言，两种技术均显示不同镜片材料的润湿性差异不大，且“相同”类型但采用不同方法制造的材料之间也无差异。这些发现与临床研究结果一致，临床研究表明体内隐形眼镜表面润湿性差异不大，这可能是由于镜片前泪膜具有明显的天然表面润湿性增强特性。
