• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

隐形眼镜材料：材料科学视角

Contact Lens Materials: A Materials Science Perspective.

作者信息

Musgrave Christopher Stephen Andrew, Fang Fengzhou

机构信息

Centre of MicroNano Manufacturing Technology (MNMT-Dublin), University College Dublin, D14 YH57 Dublin, Ireland.

State Key Laboratory of Precision Measuring Technology and Instruments, Centre of MicroNano Manufacturing Technology (MNMT), Tianjin University, Tianjin 300072, China.

出版信息

Materials (Basel). 2019 Jan 14;12(2):261. doi: 10.3390/ma12020261.

DOI:10.3390/ma12020261
PMID:30646633
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6356913/
Abstract

More is demanded from ophthalmic treatments using contact lenses, which are currently used by over 125 million people around the world. Improving the material of contact lenses (CLs) is a now rapidly evolving discipline. These materials are developing alongside the advances made in related biomaterials for applications such as drug delivery. Contact lens materials are typically based on polymer- or silicone-hydrogel, with additional manufacturing technologies employed to produce the final lens. These processes are simply not enough to meet the increasing demands from CLs and the ever-increasing number of contact lens (CL) users. This review provides an advanced perspective on contact lens materials, with an emphasis on materials science employed in developing new CLs. The future trends for CL materials are to graft, incapsulate, or modify the classic CL material structure to provide new or improved functionality. In this paper, we discuss some of the fundamental material properties, present an outlook from related emerging biomaterials, and provide viewpoints of precision manufacturing in CL development.

摘要

对于使用隐形眼镜的眼科治疗有了更多需求，目前全球有超过1.25亿人使用隐形眼镜。改进隐形眼镜（CL）材料是一门正在迅速发展的学科。这些材料随着相关生物材料在药物递送等应用方面取得的进展而不断发展。隐形眼镜材料通常基于聚合物或硅水凝胶，并采用额外的制造技术来生产最终的镜片。这些工艺根本不足以满足对隐形眼镜日益增长的需求以及隐形眼镜使用者数量的不断增加。本综述提供了关于隐形眼镜材料的前沿观点，重点是用于开发新型隐形眼镜的材料科学。隐形眼镜材料的未来趋势是嫁接、封装或修改经典的隐形眼镜材料结构，以提供新的或改进的功能。在本文中，我们讨论了一些基本的材料特性，展示了相关新兴生物材料的前景，并提供了隐形眼镜开发中精密制造的观点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d4/6356913/ee1d1be7cb9b/materials-12-00261-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d4/6356913/d6ceef0eeb73/materials-12-00261-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d4/6356913/e1f7186206ff/materials-12-00261-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d4/6356913/46a7db1d89fe/materials-12-00261-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d4/6356913/e1261c33bfd1/materials-12-00261-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d4/6356913/17c339ae34b5/materials-12-00261-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d4/6356913/25af0fb9abf4/materials-12-00261-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d4/6356913/4562c461b570/materials-12-00261-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d4/6356913/fcc5b3f954b2/materials-12-00261-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d4/6356913/a83ddbdc70f6/materials-12-00261-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d4/6356913/6dfce55aa1e5/materials-12-00261-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d4/6356913/2cb7bf695279/materials-12-00261-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d4/6356913/48362a9d6581/materials-12-00261-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d4/6356913/1724cd386476/materials-12-00261-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d4/6356913/db641fa82bf6/materials-12-00261-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d4/6356913/86e96acd7fc8/materials-12-00261-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d4/6356913/f2403cb3cf91/materials-12-00261-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d4/6356913/cb870c7b3524/materials-12-00261-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d4/6356913/ee1d1be7cb9b/materials-12-00261-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d4/6356913/d6ceef0eeb73/materials-12-00261-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d4/6356913/e1f7186206ff/materials-12-00261-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d4/6356913/46a7db1d89fe/materials-12-00261-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d4/6356913/e1261c33bfd1/materials-12-00261-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d4/6356913/17c339ae34b5/materials-12-00261-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d4/6356913/25af0fb9abf4/materials-12-00261-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d4/6356913/4562c461b570/materials-12-00261-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d4/6356913/fcc5b3f954b2/materials-12-00261-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d4/6356913/a83ddbdc70f6/materials-12-00261-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d4/6356913/6dfce55aa1e5/materials-12-00261-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d4/6356913/2cb7bf695279/materials-12-00261-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d4/6356913/48362a9d6581/materials-12-00261-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d4/6356913/1724cd386476/materials-12-00261-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d4/6356913/db641fa82bf6/materials-12-00261-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d4/6356913/86e96acd7fc8/materials-12-00261-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d4/6356913/f2403cb3cf91/materials-12-00261-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d4/6356913/cb870c7b3524/materials-12-00261-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d4/6356913/ee1d1be7cb9b/materials-12-00261-g018.jpg

相似文献

1
Contact Lens Materials: A Materials Science Perspective.隐形眼镜材料：材料科学视角
Materials (Basel). 2019 Jan 14;12(2):261. doi: 10.3390/ma12020261.
2
Biomimetic-Engineered Silicone Hydrogel Contact Lens Materials.仿生工程硅胶水凝胶隐形眼镜材料。
ACS Appl Bio Mater. 2023 Sep 18;6(9):3600-3616. doi: 10.1021/acsabm.3c00296. Epub 2023 Aug 24.
3
Phenylboronic acid modified hydrogel materials and their potential for use in contact lens based drug delivery.苯硼酸改性水凝胶材料及其在隐形眼镜给药中的应用潜力。
J Biomater Sci Polym Ed. 2022 Oct;33(15):1924-1938. doi: 10.1080/09205063.2022.2088531. Epub 2022 Jun 20.
4
Risk factors for microbial keratitis with contemporary contact lenses: a case-control study.当代隐形眼镜所致微生物性角膜炎的危险因素：一项病例对照研究。
Ophthalmology. 2008 Oct;115(10):1647-54, 1654.e1-3. doi: 10.1016/j.ophtha.2008.05.003. Epub 2008 Jul 2.
5
Uptake and release of polyhexamethylene biguanide (PHMB) from hydrogel and silicone hydrogel contact lenses using a radiolabel methodology.采用放射性标记方法研究聚六亚甲基双胍（PHMB）从水凝胶和硅水凝胶隐形眼镜中的摄取和释放。
Cont Lens Anterior Eye. 2022 Oct;45(5):101575. doi: 10.1016/j.clae.2022.101575. Epub 2022 Feb 4.
6
Selectivity and localization of lysozyme uptake in contemporary hydrogel contact lens materials.当代水凝胶隐形眼镜材料中溶菌酶摄取的选择性和定位
J Biomater Sci Polym Ed. 2017 Sep;28(13):1351-1364. doi: 10.1080/09205063.2017.1327751. Epub 2017 Jun 8.
7
The effects of the modulus of the lens material on intraocular pressure measurement through soft contact lenses.软性角膜接触镜材料模量对眼内压测量的影响。
Ir J Med Sci. 2013 Sep;182(3):331-5. doi: 10.1007/s11845-012-0881-y. Epub 2012 Dec 4.
8
Effect of Lens Care Systems on Silicone Hydrogel Contact Lens Hydrophobicity.镜片护理系统对硅水凝胶隐形眼镜疏水性的影响。
Eye Contact Lens. 2017 Mar;43(2):89-94. doi: 10.1097/ICL.0000000000000247.
9
Videokeratoscopic assessment of silicone hydrogel contact lens wettability using a new in-vitro method.使用新的体外方法评估硅水凝胶隐形眼镜的润湿性的视频角膜镜检查。
Cont Lens Anterior Eye. 2019 Dec;42(6):614-619. doi: 10.1016/j.clae.2019.07.005. Epub 2019 Aug 19.
10
Adjusting biomaterial composition to achieve controlled multiple-day release of dexamethasone from an extended-wear silicone hydrogel contact lens.调整生物材料组成以实现从长戴型硅水凝胶隐形眼镜中控制释放地塞米松的多日剂量。
J Biomater Sci Polym Ed. 2014;25(1):88-100. doi: 10.1080/09205063.2013.840228. Epub 2013 Sep 27.

引用本文的文献

1
Ocular Drug Delivery: Emerging Approaches and Advances.眼部药物递送：新兴方法与进展
Pharmaceutics. 2025 May 1;17(5):599. doi: 10.3390/pharmaceutics17050599.
2
The Behaviour of Contaflex Soft Contact Lens Material During Hydration.Contaflex软性隐形眼镜材料在水化过程中的行为。
Gels. 2025 May 21;11(5):376. doi: 10.3390/gels11050376.
3
Meta-Analysis of Materials and Treatments Used in Contact Lenses: Implications for Lens Characteristics.隐形眼镜材料与治疗方法的Meta分析：对镜片特性的影响

本文引用的文献

1
Strategies to design antimicrobial contact lenses and contact lens cases.设计抗菌隐形眼镜及隐形眼镜盒的策略。
J Mater Chem B. 2018 Apr 21;6(15):2171-2186. doi: 10.1039/c7tb03136j. Epub 2018 Mar 23.
2
A Gelated Colloidal Crystal Attached Lens for Noninvasive Continuous Monitoring of Tear Glucose.用于无创连续监测泪液葡萄糖的凝胶化胶体晶体附着透镜。
Polymers (Basel). 2017 Mar 28;9(4):125. doi: 10.3390/polym9040125.
3
Self-healing, stretchable and robust interpenetrating network hydrogels.自修复、可拉伸且强韧的互穿网络水凝胶。
Materials (Basel). 2025 Mar 25;18(7):1445. doi: 10.3390/ma18071445.
4
The Impact of Comfort Eluting Agents and Replacement Frequency on Enhancing Contact Lens Performance.舒适释药剂及更换频率对提高隐形眼镜性能的影响
Clin Ophthalmol. 2025 Mar 12;19:857-873. doi: 10.2147/OPTH.S512246. eCollection 2025.
5
Polyethylene Glycol Diacrylate Adapted Photopolymerization Material for Contact Lens with Improved Elastic Modulus Properties.用于隐形眼镜的具有改善弹性模量特性的聚乙二醇二丙烯酸酯适配光聚合材料。
Materials (Basel). 2025 Feb 13;18(4):827. doi: 10.3390/ma18040827.
6
Harnessing Non-Antibiotic Strategies to Counter Multidrug-Resistant Clinical Pathogens with Special Reference to Antimicrobial Peptides and Their Coatings.利用非抗生素策略对抗多重耐药临床病原体，特别提及抗菌肽及其涂层
Antibiotics (Basel). 2025 Jan 9;14(1):57. doi: 10.3390/antibiotics14010057.
7
Emerging trends in long-acting sustained drug delivery for glaucoma management.青光眼治疗中长效缓释药物递送的新趋势。
Drug Deliv Transl Res. 2025 Jun;15(6):1907-1934. doi: 10.1007/s13346-024-01779-4. Epub 2025 Jan 9.
8
Poly(HEMA-co-MMA) Hydrogel Scaffold for Tissue Engineering with Controllable Morphology and Mechanical Properties Through Self-Assembly.通过自组装实现形态和力学性能可控的用于组织工程的聚（甲基丙烯酸羟乙酯-共-甲基丙烯酸甲酯）水凝胶支架
Polymers (Basel). 2024 Oct 27;16(21):3014. doi: 10.3390/polym16213014.
9
Design of a square-horn hybrid plasmonic nano-antenna array using a flat lens for optical wireless applications with beam-steering capabilities.一种用于具有光束转向能力的光无线应用的、采用平面透镜的方形喇叭混合等离子体纳米天线阵列的设计。
Sci Rep. 2024 Nov 7;14(1):27049. doi: 10.1038/s41598-024-75834-y.
10
Monolithic Polyepoxide Membranes for Nanofiltration Applications and Sustainable Membrane Manufacture.用于纳滤应用和可持续膜制造的整体式聚环氧化合物膜
Polymers (Basel). 2024 Sep 11;16(18):2569. doi: 10.3390/polym16182569.
Biomater Sci. 2018 Nov 1;6(11):2932-2937. doi: 10.1039/c8bm00872h. Epub 2018 Sep 21.
4
Development of Silicone Hydrogel Antimicrobial Contact Lenses with Mel4 Peptide Coating.含Mel4肽涂层的硅水凝胶抗菌隐形眼镜的研制。
Optom Vis Sci. 2018 Oct;95(10):937-946. doi: 10.1097/OPX.0000000000001282.
5
Contact-Lens Biosensors.接触镜生物传感器。
Sensors (Basel). 2018 Aug 13;18(8):2651. doi: 10.3390/s18082651.
6
Therapeutic Contact Lenses with Polymeric Vehicles for Ocular Drug Delivery: A Review.用于眼部药物递送的含聚合物载体的治疗性隐形眼镜：综述
Materials (Basel). 2018 Jul 1;11(7):1125. doi: 10.3390/ma11071125.
7
Controlled delivery of pirfenidone through vitamin E-loaded contact lens ameliorates corneal inflammation.通过负载维生素 E 的隐形眼镜控制递送达比非尼酮可改善角膜炎症。
Drug Deliv Transl Res. 2018 Oct;8(5):1114-1126. doi: 10.1007/s13346-018-0541-5.
8
Hyaluronic acid modified MPEG-b-PAE block copolymer aqueous micelles for efficient ophthalmic drug delivery of hydrophobic genistein.透明质酸修饰的 MPEG-b-PAE 嵌段共聚物水胶束用于高效眼部传递疏水性染料木黄酮的药物
Drug Deliv. 2018 Nov;25(1):1258-1265. doi: 10.1080/10717544.2018.1474972.
9
A comprehensive review on contact lens for ophthalmic drug delivery.关于眼科药物传递用隐形眼镜的全面综述。
J Control Release. 2018 Jul 10;281:97-118. doi: 10.1016/j.jconrel.2018.05.020. Epub 2018 May 18.
10
Advances in Biomaterials for Drug Delivery.药物递送生物材料的进展
Adv Mater. 2018 May 7:e1705328. doi: 10.1002/adma.201705328.