汉坦病毒心肺综合征：免疫反应与发病机制

Hantavirus cardiopulmonary syndrome: immune response and pathogenesis.

作者信息

Borges Alessandra A, Campos Gelse M, Moreli Marcos L, Souza Ricardo L M, Aquino Victor H, Saggioro Fabiano P, Figueiredo Luiz T M

机构信息

Virology Research Center, School of Medicine of Ribeirão Preto, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto, São Paulo 14049-900, Brazil.

出版信息

Microbes Infect. 2006 Jul;8(8):2324-30. doi: 10.1016/j.micinf.2006.04.019. Epub 2006 Jun 2.

DOI:10.1016/j.micinf.2006.04.019

PMID:16793309

Abstract

Hantaviruses are emerging viruses in the Americas that cause cardiopulmonary syndrome with high lethality. The intense cellular immune response to hantavirus alters normal endothelial cell barrier functions and seems to be harmful to the host. On the other hand, the humoral immune response seems to be essential for recovery from infection.

摘要

汉坦病毒是美洲地区出现的病毒，可引发具有高致死率的心肺综合征。对汉坦病毒的强烈细胞免疫反应会改变正常内皮细胞的屏障功能，且似乎对宿主有害。另一方面，体液免疫反应似乎对感染康复至关重要。