美拉德反应抑制剂和晚期糖基化终末产物分解剂作为多种疾病的治疗药物。

Inhibitors of the Maillard reaction and AGE breakers as therapeutics for multiple diseases.

作者信息

Reddy V Prakash, Beyaz Ayse

机构信息

Department of Chemistry, University of Missouri-Rolla, Rolla, MO 65409, USA.

出版信息

Drug Discov Today. 2006 Jul;11(13-14):646-54. doi: 10.1016/j.drudis.2006.05.016.

DOI:10.1016/j.drudis.2006.05.016

PMID:16793534

Abstract

The Maillard reaction is a complex series of reactions that involve reducing-sugars and proteins, giving a multitude of end-products that are known as advanced glycation end-products (AGEs). AGEs can contribute to the pathogenesis of diabetes and neurological diseases such as Alzheimer's disease. AGEs also play a major role in vascular stiffening, atherosclerosis, osteoarthritis, inflammatory arthritis and cataracts. Thus, AGE inhibitors and AGE breakers offer a potential strategy as therapeutics for diverse diseases. Various AGE inhibitors have been developed in recent years, and their underlying mechanism is based on the attenuation of glycoxidation and/or oxidative stress by the sequestration of metal ions, reactive 1,2-dicarbonyl compounds, and reactive oxygen and reactive nitrogen species.

摘要

美拉德反应是一系列复杂的反应，涉及还原糖和蛋白质，产生多种终产物，即晚期糖基化终产物（AGEs）。AGEs可导致糖尿病和神经疾病如阿尔茨海默病的发病机制。AGEs在血管硬化、动脉粥样硬化、骨关节炎、炎性关节炎和白内障中也起主要作用。因此，AGE抑制剂和AGE裂解剂为多种疾病的治疗提供了一种潜在策略。近年来已开发出各种AGE抑制剂，其潜在机制基于通过螯合金属离子、活性1,2 - 二羰基化合物以及活性氧和活性氮物质来减轻糖氧化和/或氧化应激。