• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Restriction fragment length polymorphism analysis of azole-resistant and azole-susceptible Candida albicans strains.

作者信息

Pearce M A, Howell S A

机构信息

Institute of Dermatology, St. Thomas' Hospital, London, United Kingdom.

出版信息

J Clin Microbiol. 1991 Jul;29(7):1364-7. doi: 10.1128/jcm.29.7.1364-1367.1991.

DOI:10.1128/jcm.29.7.1364-1367.1991
PMID:1679438
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC270118/
Abstract

Restriction fragment length polymorphism analysis was performed with the endonucleases EcoRI, BglII, and HinfI on a collection of Candida albicans strains comprising eight strains randomly selected from clinical microbiology laboratory specimens, three reported azole-resistant strains from treatment failures, and several subcultures of the azole-resistant strain NCPF 3310 (also known as the Darlington strain) received from different laboratories. The results demonstrated a diversity of the restriction fragment length polymorphism patterns that were obtained and revealed that two of the proposed Darlington subcultures had patterns distinct from each other and from those of the other Darlington isolates; both were also found to have lost their azole resistance.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d647/270118/3f0b5ba4e6b0/jcm00043-0102-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d647/270118/0e9f6b1aaa1f/jcm00043-0101-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d647/270118/e10fc8467381/jcm00043-0101-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d647/270118/9e2bfed7aa60/jcm00043-0102-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d647/270118/3f0b5ba4e6b0/jcm00043-0102-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d647/270118/0e9f6b1aaa1f/jcm00043-0101-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d647/270118/e10fc8467381/jcm00043-0101-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d647/270118/9e2bfed7aa60/jcm00043-0102-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d647/270118/3f0b5ba4e6b0/jcm00043-0102-b.jpg

相似文献

1
Restriction fragment length polymorphism analysis of azole-resistant and azole-susceptible Candida albicans strains.
J Clin Microbiol. 1991 Jul;29(7):1364-7. doi: 10.1128/jcm.29.7.1364-1367.1991.
2
A comparison of the sterol content of multiple isolates of the Candida albicans Darlington strain with other clinically azole-sensitive and -resistant strains.
J Appl Bacteriol. 1990 Nov;69(5):692-6. doi: 10.1111/j.1365-2672.1990.tb01564.x.
3
Resistance mechanisms in clinical isolates of Candida albicans.白色念珠菌临床分离株中的耐药机制。
Antimicrob Agents Chemother. 2002 Jun;46(6):1704-13. doi: 10.1128/AAC.46.6.1704-1713.2002.
4
Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.白色念珠菌连续分离株中唑类耐药机制的基因型演变
Eukaryot Cell. 2007 Oct;6(10):1889-904. doi: 10.1128/EC.00151-07. Epub 2007 Aug 10.
5
Stable azole drug resistance associated with a substrain of Candida albicans from an HIV-infected patient.与一名HIV感染患者的白色念珠菌亚菌株相关的稳定唑类耐药性。
Oral Dis. 1997 May;3 Suppl 1:S102-9. doi: 10.1111/j.1601-0825.1997.tb00336.x.
6
Loss of C-5 Sterol Desaturase Activity in : Azole Resistance or Merely Trailing Growth?唑类耐药的背后：C-5 甾醇去饱和酶失活还是仅仅是生长滞后？
Antimicrob Agents Chemother. 2018 Dec 21;63(1). doi: 10.1128/AAC.01337-18. Print 2019 Jan.
7
Nucleotide substitutions in the Candida albicans ERG11 gene of azole-susceptible and azole-resistant clinical isolates.唑类敏感和唑类耐药临床分离株白色念珠菌ERG11基因中的核苷酸替换。
Acta Biochim Pol. 2013;60(4):547-52. Epub 2013 Dec 16.
8
Non-identity and authentication of two major reference strains of Candida albicans.
J Med Vet Mycol. 1991;29(4):255-61. doi: 10.1080/02681219180000371.
9
Genetic analysis of azole resistance in the Darlington strain of Candida albicans.白色念珠菌达灵顿菌株中唑类抗性的遗传分析。
Antimicrob Agents Chemother. 2000 Nov;44(11):2985-90. doi: 10.1128/AAC.44.11.2985-2990.2000.
10
Activities of the Novel Investigational Tetrazoles VT-1161 and VT-1598 Compared to the Triazole Antifungals against Azole-Resistant Strains and Clinical Isolates of .新型研究四唑 VT-1161 和 VT-1598 对唑类耐药株和临床分离株的活性比较。
Antimicrob Agents Chemother. 2019 May 24;63(6). doi: 10.1128/AAC.00341-19. Print 2019 Jun.

引用本文的文献

1
Molecular epidemiology of Candida albicans colonization and fungemia in very low birthweight infants.极低出生体重儿白色念珠菌定植与真菌血症的分子流行病学
Can J Infect Dis. 1993 Nov;4(6):322-7. doi: 10.1155/1993/495480.
2
Genetic analysis of azole resistance in the Darlington strain of Candida albicans.白色念珠菌达灵顿菌株中唑类抗性的遗传分析。
Antimicrob Agents Chemother. 2000 Nov;44(11):2985-90. doi: 10.1128/AAC.44.11.2985-2990.2000.
3
Contribution of molecular typing methods and antifungal susceptibility testing to the study of a candidemia cluster in a burn care unit.

本文引用的文献

1
Repetitive DNA of Candida albicans: nuclear and mitochondrial components.白色念珠菌的重复DNA：核成分和线粒体成分
J Bacteriol. 1984 Mar;157(3):918-24. doi: 10.1128/jb.157.3.918-924.1984.
2
Modified response to ketoconazole of Candida albicans from a treatment failure.白色念珠菌对酮康唑的反应从治疗失败转变。
Lancet. 1983 Mar 19;1(8325):642-3. doi: 10.1016/s0140-6736(83)91809-3.
3
The lipid composition of azole-sensitive and azole-resistant strains of Candida albicans.白色念珠菌唑类敏感菌株和唑类耐药菌株的脂质组成。
分子分型方法和抗真菌药敏试验对烧伤护理单元念珠菌血症聚集性病例研究的贡献。
J Clin Microbiol. 1995 Dec;33(12):3278-83. doi: 10.1128/jcm.33.12.3278-3283.1995.
4
Oligonucleotide fingerprinting of isolates of Candida species other than C. albicans and of atypical Candida species from human immunodeficiency virus-positive and AIDS patients.对来自人类免疫缺陷病毒阳性患者和艾滋病患者的白色念珠菌以外的念珠菌属分离株及非典型念珠菌属进行寡核苷酸指纹分析。
J Clin Microbiol. 1993 Aug;31(8):2124-33. doi: 10.1128/jcm.31.8.2124-2133.1993.
5
Typing of Candida krusei clinical isolates by restriction endonuclease analysis and hybridization with CkF1,2 DNA probe.通过限制性内切酶分析以及与CkF1,2 DNA探针杂交对克柔念珠菌临床分离株进行分型。
J Clin Microbiol. 1994 Jul;32(7):1691-9. doi: 10.1128/jcm.32.7.1691-1699.1994.
6
Candida albicans genotyping in studies with patients with AIDS developing resistance to fluconazole.对艾滋病患者中出现氟康唑耐药性的研究中的白色念珠菌基因分型。
J Clin Microbiol. 1993 Nov;31(11):2933-7. doi: 10.1128/jcm.31.11.2933-2937.1993.
7
Colony morphotype on Sabouraud-triphenyltetrazolium agar: a simple and inexpensive method for Candida subspecies discrimination.沙氏-三苯基四氮唑琼脂上的菌落形态型：一种简单且廉价的念珠菌亚种鉴别方法。
J Clin Microbiol. 1992 Oct;30(10):2748-52. doi: 10.1128/jcm.30.10.2748-2752.1992.
J Gen Microbiol. 1986 Sep;132(9):2421-31. doi: 10.1099/00221287-132-9-2421.
4
Inhibition of 14 alpha-sterol demethylase activity in Candida albicans Darlington does not correlate with resistance to azole.白色念珠菌达灵顿株中14α-甾醇脱甲基酶活性的抑制与对唑类药物的耐药性无关。
J Med Vet Mycol. 1987 Oct;25(5):329-33.
5
Strain differentiation of Candida albicans by morphotyping.通过形态分型对白色念珠菌进行菌株分化。
Epidemiol Infect. 1987 Oct;99(2):421-8. doi: 10.1017/s0950268800067911.
6
Candida species and C. albicans biotypes in women attending clinics in genitourinary medicine.在泌尿生殖医学诊所就诊的女性中的念珠菌属及白色念珠菌生物型。
J Med Microbiol. 1989 May;29(1):51-4. doi: 10.1099/00222615-29-1-51.
7
The identification of Candida albicans strains by restriction fragment length polymorphism analysis of DNA.通过DNA限制性片段长度多态性分析鉴定白色念珠菌菌株。
J Med Vet Mycol. 1989;27(6):431-4.
8
Assessment of DNA fingerprinting for rapid identification of outbreaks of systemic candidiasis.评估DNA指纹图谱用于快速鉴定系统性念珠菌病暴发情况
BMJ. 1989 Feb 11;298(6670):354-7. doi: 10.1136/bmj.298.6670.354.
9
A comparison of the sterol content of multiple isolates of the Candida albicans Darlington strain with other clinically azole-sensitive and -resistant strains.
J Appl Bacteriol. 1990 Nov;69(5):692-6. doi: 10.1111/j.1365-2672.1990.tb01564.x.
10
Epidemiological investigation of patients with vulvovaginal candidosis. Application of a resistogram method for strain differentiation of Candida albicans.外阴阴道念珠菌病患者的流行病学调查。应用电阻图法对白色念珠菌进行菌株鉴别。
Br J Vener Dis. 1979 Oct;55(5):357-61. doi: 10.1136/sti.55.5.357.