Scott D, Barnes A, Lister M, Arkell P
The Pharmacy, Dudley Road Hospital, Birmingham, UK.
J Hosp Infect. 1991 Jun;18 Suppl B:51-5. doi: 10.1016/0195-6701(91)90263-8.
Four similar-looking preparations containing 4% chlorhexidine ('Hibiscrub', Surgiscrub', 'Uniscrub', 'Macrocide') were compared in a single-blind, randomized study in a group of 73 volunteers. The volunteers washed their hands with each preparation ten times over 9 h, one preparation day-1 on each of four days over two weeks. The acceptability of the agents was assessed using visual analogue scales which were analysed by paired t-test. There were marked differences between the products. 'Uniscrub' smelled worse (P less than 0.003) and felt worse than the others (P less than 0.003). 'Hibiscrub' lathered well but 'Macrocide' was found easiest to rinse off. 'Hibiscrub' and 'Surgiscrub' were the least irritant and had the best visual appearance. Despite apparent similarities, these chlorhexidine formulations varied in acceptability to users.
在一项针对73名志愿者的单盲随机研究中，对四种外观相似、含4%氯己定的制剂（“洗必泰擦洗剂”、“外科手术擦洗剂”、“通用擦洗剂”、“强力杀菌剂”）进行了比较。志愿者在9小时内用每种制剂洗手10次，在两周内的四天里，每天使用一种制剂，第一天使用一种。使用视觉模拟量表评估这些制剂的可接受性，并通过配对t检验进行分析。这些产品之间存在显著差异。“通用擦洗剂”气味更难闻（P<0.003），给人的感觉也比其他产品更差（P<0.003）。“洗必泰擦洗剂”泡沫丰富，但“强力杀菌剂”最容易冲洗干净。“洗必泰擦洗剂”和“外科手术擦洗剂”刺激性最小，外观也最好。尽管这些氯己定制剂表面上相似，但使用者对它们的可接受性各不相同。
