核磷蛋白与癌症。

Nucleophosmin and cancer.

作者信息

Grisendi Silvia, Mecucci Cristina, Falini Brunangelo, Pandolfi Pier Paolo

机构信息

Cancer Biology & Genetics Program, Department of Pathology, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

出版信息

Nat Rev Cancer. 2006 Jul;6(7):493-505. doi: 10.1038/nrc1885.

DOI:10.1038/nrc1885

PMID:16794633

Abstract

NPM1 is a crucial gene to consider in the context of the genetics and biology of cancer. NPM1 is frequently overexpressed, mutated, rearranged and deleted in human cancer. Traditionally regarded as a tumour marker and a putative proto-oncogene, it has now also been attributed with tumour-suppressor functions. Therefore, NPM can contribute to oncogenesis through many mechanisms. The aim of this review is to analyse the role of NPM in cancer, and examine how deregulated NPM activity (either gain or loss of function) can contribute to tumorigenesis.

摘要

在癌症的遗传学和生物学背景下，NPM1是一个需要考虑的关键基因。NPM1在人类癌症中经常过度表达、发生突变、重排和缺失。传统上被视为肿瘤标志物和假定的原癌基因，现在它也被赋予了肿瘤抑制功能。因此，NPM可通过多种机制促进肿瘤发生。本综述的目的是分析NPM在癌症中的作用，并探讨NPM活性失调（功能获得或丧失）如何促进肿瘤发生。