Yahaya I A, Isah H S, Anaja P O
Department of Chemical Pathology, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria.
Niger Postgrad Med J. 2006 Jun;13(2):95-8.
To assess the usefulness of fructosamine in evaluating the glycaemic status in patients with sickle cell anaemia.
Serum fructosamine, glucose, albumin and bilirubin were measured in one hundred and fifty patients with sickle cell anaemia (HbSS), fifty poorly controlled diabetics and one hundred healthy control subjects. Fructosamine was assayed using the method of Johnson et al.
None of the HbSS patients had hyperglycaemia. Serum fructosamine was significantly higher in the poorly controlled Diabetics compared to the HbSS patients and the Controls. The mean serum albumin levels were within the laboratory's reference interval in the three groups of subjects studied. There was no significant correlation between fructosamine and normal serum albumin in the three groups of subjects. Moderately raised serum bilirubin concentrations in the HbSS patients did not cause any significant interference in the assay of fructosamine in the patients.
Serum fructosamine could be reliably employed as a measure of glycaemic status of patients with sickle cell anaemia with moderate hyperbilirubinaemia.
评估果糖胺在评估镰状细胞贫血患者血糖状态中的作用。
对150例镰状细胞贫血（HbSS）患者、50例血糖控制不佳的糖尿病患者和100例健康对照者测定血清果糖胺、葡萄糖、白蛋白和胆红素。采用Johnson等人的方法测定果糖胺。
HbSS患者均无高血糖。与HbSS患者和对照组相比，血糖控制不佳的糖尿病患者血清果糖胺显著更高。在研究的三组受试者中，平均血清白蛋白水平均在实验室参考区间内。三组受试者中，果糖胺与正常血清白蛋白之间无显著相关性。HbSS患者血清胆红素浓度适度升高，对患者果糖胺测定未造成任何显著干扰。
血清果糖胺可可靠地用于评估伴有中度高胆红素血症的镰状细胞贫血患者的血糖状态。
