五个与癌症相关的大鼠基因的染色体定位：两个甲状腺激素受体（ERBA）基因、两个ERBB基因和成视网膜细胞瘤基因。
Chromosomal assignment of five cancer-associated rat genes: two thyroid hormone receptor (ERBA) genes, two ERBB genes and the retinoblastoma gene.
作者信息
Szpirer C, Szpirer J, Rivière M, Ingvarsson S, Vennström B, Islam M Q, Levan G
机构信息
Département de Biologie Moléculaire, Université Libre de Bruxelles, Rhode-St-Genèse, Brussels, Belgium.
出版信息
Oncogene. 1991 Aug;6(8):1319-24.
Using a panel of somatic cell hybrids that segregate rat chromosomes, the localization of five cancer-related rat genes was determined: (i) two thyroid receptor genes, THRA1/ERBA1 and THRB/ERBA2 on chromosomes 10 and 15 respectively, (ii) two ERBB genes, namely the epidermal growth factor gene (EGFR, also called ERBB1) and the ERBB2 gene (also designated neu) on chromosomes 14 and 10 respectively, and (iii) the retinoblastoma gene, RB1, on chromosome 15. The THRA1/ERBA1 and ERBB2/neu genes are thus included in a synteny group, conserved on rat chromosomes 10 and human chromosome arm 17q.
利用一组能分离大鼠染色体的体细胞杂种，确定了五个与癌症相关的大鼠基因的定位：（i）两个甲状腺受体基因，THRA1/ERBA1和THRB/ERBA2分别位于10号和15号染色体上；（ii）两个ERBB基因，即表皮生长因子基因（EGFR，也称为ERBB1）和ERBB2基因（也称为neu）分别位于14号和10号染色体上；以及（iii）视网膜母细胞瘤基因RB1位于15号染色体上。因此，THRA1/ERBA1和ERBB2/neu基因包含在一个同线基因群中，该同线基因群在大鼠10号染色体和人类17q染色体臂上保守。
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