在NIH3T3细胞中，对配体激活的表皮生长因子受体（EGFR）和神经生长因子受体（neu）酪氨酸激酶有相似的早期基因反应。
Similar early gene responses to ligand-activated EGFR and neu tyrosine kinases in NIH3T3 cells.
作者信息
Koskinen P, Lehväslaiho H, MacDonald-Bravo H, Alitalo K, Bravo R
机构信息
Department of Virology, University of Helsinki, Finland.
出版信息
Oncogene. 1990 Apr;5(4):615-8.
PMID:1970155
Abstract
We have compared the responses of serum-inducible immediate early genes to ligand activation of the epidermal growth factor receptor (EGFR) or a hybrid EGFR/neu receptor containing the intracellular domain of the neu proto-oncogene. Few differences in mRNA induction kinetics were found, emphasizing the functional similarity of these structurally related tyrosine kinases.
摘要
我们比较了血清诱导型即刻早期基因对表皮生长因子受体（EGFR）或含有神经原癌基因细胞内结构域的杂交EGFR/neu受体配体激活的反应。未发现mRNA诱导动力学有明显差异，这突出了这些结构相关的酪氨酸激酶的功能相似性。
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