编码多巴脱羧酶（DDC）和谷氨酸脱羧酶（GAD1和GAD2）的大鼠基因的定位
Assignment of the rat genes coding for dopa decarboxylase (DDC) and glutamic acid decarboxylases (GAD1 and GAD2).
作者信息
Vassort C, Rivière M, Bruneau G, Gros F, Thibault J, Levan G, Szpirer J, Szpirer C
机构信息
Laboratoire de Biocheimie Cellulaire, Collège de France, Paris.
出版信息
Mamm Genome. 1993;4(4):202-6. doi: 10.1007/BF00417563.
By use of rat cDNA probes and a panel of cell hybrids segregating rat chromosomes, the genes encoding three pyridoxal 5'-phosphate (PLP)-dependent decarboxylases--namely, DOPA-decarboxylase (Ddc), glutamic acid decarboxylase 1 and 2 (Gad1 and Gad2)--were assigned to rat Chromosomes (Chrs) 14, 3, and 17, respectively. If one takes into account chromosome localizations in the human and the mouse, the present results (i) show that a synteny group is retained on rat Chr 14, human Chr 7, and mouse Chr 11 (Ddc); (ii) strengthen the homology relation known between rat Chr 3 and human and mouse Chrs 2 (Gad1); (iii) suggest that rat Chr 17 has no extensive homology to any human chromosome; and (iv) suggest the order (Prl, Fdp)--Tpl2--Gad2 on the rat Chr 17.
利用大鼠cDNA探针和一组分离大鼠染色体的细胞杂种，编码三种5'-磷酸吡哆醛（PLP）依赖性脱羧酶的基因——即多巴脱羧酶（Ddc）、谷氨酸脱羧酶1和2（Gad1和Gad2）——分别被定位到大鼠染色体（Chrs）14、3和17上。如果考虑人类和小鼠的染色体定位，目前的结果（i）表明在大鼠Chr 14、人类Chr 7和小鼠Chr 11（Ddc）上保留了一个同线群；（ii）加强了已知的大鼠Chr 3与人类和小鼠Chrs 2（Gad1）之间的同源关系；（iii）表明大鼠Chr 17与任何人类染色体都没有广泛的同源性；（iv）表明在大鼠Chr 17上的顺序为（Prl，Fdp）--Tpl2--Gad2。
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