Chellappan Savitha, Roy Subarna, Nagmoti Jyoti M, Tabassum Wahida, Hoti S L, Bhattacharyya Mrinal Kanti, Nina Praveen Balabaskaran
Indian Council of Medical Research - National Institute of Traditional Medicine, Belagavi, Karnataka, India.
Department of Microbiology, K.L.E. University, Belagavi, Karnataka, India.
Indian J Med Microbiol. 2020 Apr-Jun;38(2):213-215. doi: 10.4103/ijmm.IJMM_20_28.
Prohibitins (PHBs) are evolutionarily conserved mitochondrial integral membrane proteins, shown to regulate mitochondrial structure and function, and can be classified into PHB1 and PHB2. PHB1 and PHB2 have been shown to interact with each other, and form heterodimers in mitochondrial inner membrane. Plasmodium falciparum has orthologues of PHB1 and PHB2 in its genome, and their role is unclear. Here, by homology modelling and yeast two-hybrid analysis, we show that putative Plasmodium PHBs (Pf PHB1 and Pf PHB2) interact with each other, which suggests that they could form supercomplexes of heterodimers in Plasmodium, the functional form required for optimum mitochondrial function.
禁止素（PHBs）是进化上保守的线粒体整合膜蛋白，已证明其可调节线粒体结构和功能，可分为PHB1和PHB2。已证明PHB1和PHB2可相互作用，并在线粒体内膜形成异二聚体。恶性疟原虫基因组中有PHB1和PHB2的直系同源物，但其作用尚不清楚。在此，通过同源建模和酵母双杂交分析，我们表明推定的疟原虫PHBs（Pf PHB1和Pf PHB2）相互作用，这表明它们可能在疟原虫中形成异二聚体的超复合物，这是最佳线粒体功能所需的功能形式。
