Cabanillas Miguel, Pérez-Pérez Lidia, Sánchez-Aguilar Dolores, Fernández-Redondo Virginia, Toribio Jaime
Departamento de Dermatología, Complejo Hospitalario Universitario, Facultad de Medicina, Santiago de Compostela, España.
Actas Dermosifiliogr. 2006 Apr;97(3):196-9. doi: 10.1016/s0001-7310(06)73379-8.
Acrokeratosis paraneoplastica (Bazex syndrome) is characterized by an acral eruption with a psoriasiform appearance, which usually presents simultaneously with an underlying neoplasm. We describe the case of a 64-year-old male who presented with a two-month history of pruritic, flaky, erythematous lesions on the palms, backs of the fingers and toes and pinnae, accompanied by bullous lesions. The patient also reported progressive dysphagia in the last six months, and general wasting with a loss of 15 kg. The digestive endoscopy revealed a squamous cell carcinoma in the proximal esophagus. The histopathological study of the bullous lesions showed the presence of a subepidermal bulla, and direct immunofluorescence revealed granular deposits of IgG, IgA and C3 in the basal membrane of the healthy perilesional skin. These clinical/pathological findings support the existence of an immunological pathogenic mechanism related to this entity.
副肿瘤性肢端角化病（巴泽克斯综合征）的特征是肢端出现银屑病样皮疹，通常与潜在肿瘤同时出现。我们报告一例64岁男性患者，其手掌、手指背、脚趾和耳廓出现瘙痒、片状、红斑性皮损伴大疱性皮损，病程两个月。患者还报告在过去六个月中出现进行性吞咽困难，体重减轻15公斤，全身消瘦。消化内镜检查发现食管上段鳞状细胞癌。大疱性皮损的组织病理学研究显示表皮下大疱形成，直接免疫荧光显示在健康的皮损周围皮肤基底膜中有IgG、IgA和C3颗粒沉积。这些临床/病理结果支持与该疾病相关的免疫致病机制的存在。
