Department of Dermatology, Shanghai Tenth People's Hospital9, Tongji University School of Medicine, No.301, Middle Yanchang Road, Shanghai, 200072, China.
Department of Pathology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China.
World J Surg Oncol. 2017 Nov 25;15(1):208. doi: 10.1186/s12957-017-1274-5.
Malignant acanthosis nigricans (MAN), characterized by the presence of a hyperpigmented, velvety cutaneous thickening, is recognized as a cutaneous sign of internal malignancy. Few MAN has been reported in the Asian race ever before.
Here, we report a rare case of MAN with severe mucosa and soles and extraordinary facial involvement in the Asian race. A 74-year-old man presented with hyperkeratotic eruption for 7 months. Physical examination revealed hyperkeratotic plaques on the face, dorsal skin of fingers and heels, and papillomatosis of buccal mucosa. Biopsy findings from skin lesion revealed hyperkeratosis, papillomatosis, and hyperpigmentation of the basal layer. The endoscopic ultrasound with biopsy of the gastric tissue revealed gastric cardia tubular adenocarcinoma. The patient was diagnosed with MAN associated with gastric adenocarcinoma, immediately following tumor resection and lymphadenectomy. A slight improvement was seen in the skin condition but died of cancer cachexia 3 months later.
We report our typical patient to highlight the importance of MAN, which was an early clue to the discovery of gastric adenocarcinoma.
恶性黑棘皮病（Malignant Acanthosis Nigricans，MAN）的特征是存在色素沉着、天鹅绒样皮肤增厚，被认为是内部恶性肿瘤的皮肤标志。在此之前，亚洲人种中鲜有报道过 MAN。
在此，我们报告了一例罕见的亚洲人种 MAN 病例，其黏膜和脚底严重受累，面部受累异常。一名 74 岁男性因角化过度性皮疹就诊 7 个月。体格检查显示面部、手指背部和足跟部有角化过度斑块，口腔颊黏膜有乳头瘤样病变。皮肤病变的活检结果显示角化过度、乳头瘤样和基底层色素沉着。胃组织的内镜超声和活检显示胃贲门管状腺癌。患者被诊断为 MAN 合并胃腺癌，在肿瘤切除和淋巴结清扫后立即进行了治疗。皮肤状况略有改善，但 3 个月后死于癌症恶病质。
我们报告了一个典型的患者，以强调 MAN 的重要性，它是发现胃腺癌的早期线索。
