Sator Paul-Gunther, Breier Friedrich, Gschnait Friedrich
Department of Dermatology, Municipal Hospital Lainz, Vienna, Austria.
J Am Acad Dermatol. 2006 Dec;55(6):1103-5. doi: 10.1016/j.jaad.2006.05.064. Epub 2006 Aug 28.
Acrokeratosis paraneoplastica (Bazex's syndrome) is a rare obligate paraneoplastic dermatosis characterized by erythematosquamous lesions localized symmetrically at the acral sites. The condition almost exclusively affects Caucasian men older than 40 years. It is usually associated with primary malignant neoplasms of the upper aerodigestive tract. In most cases, the skin changes precede the clinical manifestation of the underlying neoplasm. The dermatosis can be cured only by removal of the underlying carcinoma. We describe a case of acrokeratosis paraneoplastica associated with a retroperitoneal liposarcoma in a 71-year-old Caucasian man. The liposarcoma was surgically removed but recurred several times, with acrokeratosis paraneoplastica showing a parallel development. We, therefore, add liposarcoma to the growing list of malignant neoplasms associated with acrokeratosis paraneoplastica.
副肿瘤性肢端角化病（巴泽克斯综合征）是一种罕见的、必然与肿瘤相关的皮肤病，其特征为红斑鳞屑性损害对称分布于肢体末端部位。该病几乎仅累及40岁以上的白种男性。它通常与上呼吸消化道的原发性恶性肿瘤相关。在大多数情况下，皮肤改变先于潜在肿瘤的临床表现出现。只有切除潜在的癌肿，这种皮肤病才能治愈。我们描述了一例71岁白种男性副肿瘤性肢端角化病合并腹膜后脂肪肉瘤的病例。脂肪肉瘤经手术切除，但多次复发，同时副肿瘤性肢端角化病也呈现平行发展。因此，我们将脂肪肉瘤添加到与副肿瘤性肢端角化病相关的恶性肿瘤不断增加的列表中。
