Romeo Melissa, Mohlenhoff Brian, Jennings Michael, Diem Max
Department of Chemistry and Biochemistry, City University of New York, Hunter College, New York, NY 10021, USA.
Biochim Biophys Acta. 2006 Jul;1758(7):915-22. doi: 10.1016/j.bbamem.2006.05.010. Epub 2006 May 19.
We report results from a study of human and canine mucosal cells, investigated by infrared micro-spectroscopy, and analyzed by methods of multivariate statistics. We demonstrate that the infrared spectra of individual cells are sensitive to the stage of maturation, and that a distinction between healthy and diseased cells will be possible. Since this report is written for an audience not familiar with infrared micro-spectroscopy, a short introduction into this field is presented along with a summary of principal component analysis.
我们报告了一项关于人类和犬类黏膜细胞的研究结果,该研究采用红外显微光谱法进行调查,并通过多元统计方法进行分析。我们证明,单个细胞的红外光谱对成熟阶段敏感,并且有可能区分健康细胞和患病细胞。由于本报告是为不熟悉红外显微光谱法的读者撰写的,因此在介绍主成分分析总结的同时,对该领域进行了简要介绍。