Chiandussi S, Biasotto M, Dore F, Cavalli F, Cova M A, Di Lenarda R
Department of Dental Sciences, University of Trieste, Trieste, Italy.
Dentomaxillofac Radiol. 2006 Jul;35(4):236-43. doi: 10.1259/dmfr/27458726.
It is important to recognize osteonecrosis of the jaws in patients treated with bisphosphonates because an early diagnosis can make a significant difference to the outcome of the disease. The aim of this study is to describe the radiological features of bisphosphonate osteonecrosis (BON) in order to aid its prompt recognition.
A conventional radiograph, a computed tomograph (CT), a magnetic resonance image (MRI) and a 99Tc(m)-MDP 3-phase bone scan were carried out for 11 patients with BON. The main imaging findings of osteonecrosis are described.
Conventional radiography and CT displayed osteolytic lesions with the involvement of cortical bone. MRI demonstrated the characteristic features of osteonecrosis and the oedema of soft tissues. Both CT and MRI were very useful in defining the extent of the lesions. 99Tc(m)-MDP three-phase bone scan was the most sensitive tool to detect the osteonecrosis at an early stage.
99Tc(m)-MDP three-phase bone scans who could be used as a screening test to detect subclinical osteonecrosis in patients who have received bisphosphonates. CT scans and MRI are useful in defining the features and extent of osteolytic lesions.
认识接受双膦酸盐治疗患者的颌骨骨坏死很重要，因为早期诊断对疾病的预后有显著影响。本研究的目的是描述双膦酸盐性骨坏死（BON）的放射学特征，以帮助其得到及时识别。
对11例BON患者进行了常规X线片、计算机断层扫描（CT）、磁共振成像（MRI）及99锝（m）-亚甲基二膦酸盐（MDP）三相骨扫描。描述了骨坏死的主要影像学表现。
常规X线片和CT显示溶骨性病变累及皮质骨。MRI显示了骨坏死及软组织水肿的特征性表现。CT和MRI在确定病变范围方面都非常有用。99锝（m）-MDP三相骨扫描是早期检测骨坏死最敏感的工具。
99锝（m）-MDP三相骨扫描可用作筛查试验，以检测接受双膦酸盐治疗患者的亚临床骨坏死。CT扫描和MRI有助于确定溶骨性病变的特征和范围。
