He Mingguang, Foster Paul J, Ge Jian, Huang Wenyong, Zheng Yingfeng, Friedman David S, Lee Pak Sang, Khaw Peng T
Institute of Ophthalmology, University College London, and Glaucoma Research Unit, Moorfields Eye Hospital, United Kingdom.
Invest Ophthalmol Vis Sci. 2006 Jul;47(7):2782-8. doi: 10.1167/iovs.06-0051.
To assess the prevalence and mechanism of glaucoma in adults living in an urban area of southern China.
Random clustering sampling was used to identify adults aged 50 years and over in Liwan District, Guangzhou. Glaucoma was diagnosed with the ISGEO (International Society of Geographical and Epidemiological Ophthalmology) classification scheme. All subjects underwent gonioscopy.
In the study, 1504 subjects (75.3% participation rate) were examined, with a crude prevalence of all glaucoma of 3.8% (95% confidence interval [CI], 2.8%-4.8%). Primary open-angle glaucoma (POAG) was found in 2.1% (95% CI, 1.4%-2.8%) and primary angle-closure glaucoma (PACG) in 1.5% (95% CI, 0.8%-2.1%). The prevalence of all glaucoma was significantly higher in older people and men.
POAG was more common than PACG in this southern Chinese population, with rates similar to those reported in Chinese Singaporeans. The age-adjusted rate of POAG was similar to that found in European-derived populations, but PACG was more common among Chinese, indicating that there is a large burden of glaucoma in the Chinese people.
评估中国南方城市地区成年人青光眼的患病率及发病机制。
采用随机整群抽样法，在广州荔湾区选取50岁及以上的成年人。青光眼的诊断采用国际地理与流行病学眼科学会（ISGEO）分类方案。所有受试者均接受前房角镜检查。
本研究共检查了1504名受试者（参与率为75.3%），青光眼的总体患病率为3.8%（95%置信区间[CI]，2.8%-4.8%）。原发性开角型青光眼（POAG）的患病率为2.1%（95%CI，1.4%-2.8%），原发性闭角型青光眼（PACG）的患病率为1.5%（95%CI，0.8%-2.1%）。青光眼的总体患病率在老年人和男性中显著更高。
在这一中国南方人群中，POAG比PACG更常见，其患病率与新加坡华人的报告相似。POAG的年龄调整患病率与欧洲裔人群相似，但PACG在中国人中更为常见，这表明青光眼在中国人群中的负担较重。
