Bonkowski Michael S, Pamenter Richard W, Rocha Juliana S, Masternak Michal M, Panici Jacob A, Bartke Andrzej
Department of Physiology and Internal Medicine-Geriatrics Research, Southern Illinois University School of Medicine, Springfield. IL 62794-9628, USA.
J Gerontol A Biol Sci Med Sci. 2006 Jun;61(6):562-7. doi: 10.1093/gerona/61.6.562.
There is conflicting information on the physiological role of growth hormone (GH) in the control of aging. This study reports dual-energy x-ray absorptiometry (DXA) measurements of body composition and bone characteristics in young, adult, and aged long-lived GH receptor knockout (GHR-KO) and normal mice to determine the effects of GH resistance during aging. Compared to controls, GHR-KO mice showed an increased percentage of body fat. GHR-KO mice have reduced total-body bone mineral density (BMD), bone mineral content, and bone area, but these parameters increased with age. In addition, GHR-KO mice have decreased femur length, femur BMD, and lower lumbar BMD compared to controls in all age groups. These parameters also continued to increase with age. Our results indicate that GH resistance alters body composition, bone growth, and bone maintenance during aging in GHR-KO mice.
关于生长激素（GH）在衰老控制中的生理作用，存在相互矛盾的信息。本研究报告了对年轻、成年和老年的长寿生长激素受体敲除（GHR-KO）小鼠和正常小鼠进行双能X线吸收法（DXA）测量身体成分和骨骼特征，以确定衰老过程中生长激素抵抗的影响。与对照组相比，GHR-KO小鼠的体脂百分比增加。GHR-KO小鼠的全身骨矿物质密度（BMD）、骨矿物质含量和骨面积降低，但这些参数随年龄增长而增加。此外，在所有年龄组中，与对照组相比，GHR-KO小鼠的股骨长度、股骨BMD和腰椎BMD均降低。这些参数也随年龄持续增加。我们的结果表明，生长激素抵抗会改变GHR-KO小鼠衰老过程中的身体成分、骨骼生长和骨骼维持。
