Yaldo M K, Shin D H, Parrow K A, Lee S H, Lee S Y
Kresge Eye Institute, Wayne State University, Detroit, MI 48201.
Ophthalmology. 1991 Jul;98(7):1075-8. doi: 10.1016/s0161-6420(91)32189-4.
The short-term additive effect and side effects of adding 1% apraclonidine hydrochloride to nonselective beta-blockers were investigated in 21 patients with ocular hypertension or early primary open-angle glaucoma. After a unilateral single dose application of topical 1% apraclonidine hydrochloride, intraocular pressure (IOP), heart rate, and interpalpebral distance were measured. The mean IOP of treated eyes showed a decline from a baseline of 20.0 +/- 3.0 mmHg to 18.1 +/- 3.2 mmHg at 1 hour (P less than 0.005), 16.5 +/- 2.6 mmHg at 2 hours (P less than 0.001), 15.2 +/- 2.5 mmHg at 3 hours (P less than 0.001), 18.5 +/- 3.0 mmHg at 12 hours (P = 0.02), and 19.2 +/- 2.9 mmHg at 24 hours (P = 0.2). No statistically significant change in the heart rate was seen. The interpalpebral distance of the treated eyes showed a significant increase (P less than 0.05) at all time intervals except 24 hours (P = 0.17). The authors conclude that 1% apraclonidine hydrochloride provides an additive pressure-lowering effect to nonselective beta-blockers for at least 12 hours after a single application, and shows promise as a useful adjunctive agent for short-term use in glaucoma therapy.
在21例高眼压症或早期原发性开角型青光眼患者中，研究了在非选择性β受体阻滞剂基础上加用1%盐酸阿可乐定的短期附加效应和副作用。在单侧单次局部应用1%盐酸阿可乐定后，测量眼压（IOP）、心率和睑裂间距。治疗眼的平均眼压在1小时时从基线的20.0±3.0 mmHg降至18.1±3.2 mmHg（P<0.005），2小时时为16.5±2.6 mmHg（P<0.001），3小时时为15.2±2.5 mmHg（P<0.001），12小时时为18.5±3.0 mmHg（P = 0.02），24小时时为19.2±2.9 mmHg（P = 0.2）。心率未见统计学显著变化。治疗眼的睑裂间距在除24小时外的所有时间间隔均有显著增加（P<0.05），24小时时（P = 0.17）。作者得出结论，单次应用1%盐酸阿可乐定后，至少在12小时内可为非选择性β受体阻滞剂提供附加的降眼压作用，有望作为青光眼治疗短期使用的有用辅助药物。
