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Tumourigenic multidrug-resistant HT1080 cells do not overexpress receptors for epidermal growth factor.

作者信息

Slovak M L, Mirski S E, Cole S P, Gerlach J H, Yohem K H, Trent J M

机构信息

Department of Cytogenetics, City of Hope National Medical Center, Duarte, California 91010.

出版信息

Br J Cancer. 1991 Aug;64(2):296-8. doi: 10.1038/bjc.1991.295.

DOI:10.1038/bjc.1991.295
PMID:1679997
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1977511/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f0b/1977511/a996c8c71b24/brjcancer00072-0099-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f0b/1977511/c7abf5e16ba9/brjcancer00072-0099-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f0b/1977511/a996c8c71b24/brjcancer00072-0099-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f0b/1977511/c7abf5e16ba9/brjcancer00072-0099-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f0b/1977511/a996c8c71b24/brjcancer00072-0099-b.jpg

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1
Tumourigenic multidrug-resistant HT1080 cells do not overexpress receptors for epidermal growth factor.致瘤性多药耐药HT1080细胞不会过度表达表皮生长因子受体。
Br J Cancer. 1991 Aug;64(2):296-8. doi: 10.1038/bjc.1991.295.
2
The immunogenic properties of drug-resistant murine tumor cells do not correlate with expression of the MDR phenotype.耐药小鼠肿瘤细胞的免疫原性特性与多药耐药（MDR）表型的表达不相关。
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3
Amplification and overexpression of the P-glycoprotein genes and differential amplification of three other genes in SEWA murine multidrug-resistant cells.SEWA小鼠多药耐药细胞中P-糖蛋白基因的扩增与过表达以及其他三个基因的差异扩增
Hereditas. 1988;108(2):251-8. doi: 10.1111/j.1601-5223.1988.tb00310.x.
4
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5
Molecular analysis of two human doxorubicin-resistant cell lines: evidence for differing multidrug resistance mechanisms.
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6
Crosstalk between epidermal growth factor receptor and P-glycoprotein in actinomycin D-resistant Chinese hamster lung cells.
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Multidrug resistance (MDR 1) in leukemia: is it time to test?白血病中的多药耐药性（MDR 1）：是时候进行检测了吗？
Blood. 1992 Jan 15;79(2):295-8.
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Effect of calcium antagonists on the chemosensitivity of two multidrug-resistant human tumour cell lines which do not overexpress P-glycoprotein.钙拮抗剂对两种未过表达P-糖蛋白的多药耐药人肿瘤细胞系化学敏感性的影响。
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HT1080/DR4: a P-glycoprotein-negative human fibrosarcoma cell line exhibiting resistance to topoisomerase II-reactive drugs despite the presence of a drug-sensitive topoisomerase II.HT1080/DR4：一种P-糖蛋白阴性的人纤维肉瘤细胞系，尽管存在对药物敏感的拓扑异构酶II，但对拓扑异构酶II反应性药物仍表现出抗性。
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Mechanism of multidrug resistance.多药耐药机制。
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引用本文的文献

1
Human cell lines as models for multidrug resistance in solid tumours.人类细胞系作为实体瘤多药耐药性的模型。
Cytotechnology. 1993;12(1-3):231-56. doi: 10.1007/BF00744666.

本文引用的文献

1
Expression of drug sensitivity and tumorigenicity in intraspecies hybrids between 9-hydroxyellipticine-sensitive and -resistant cells.9-羟基玫瑰树碱敏感细胞与耐药细胞种内杂交体中药物敏感性和致瘤性的表达
Cancer Res. 1984 Oct;44(10):4587-93.
2
Properties of the receptor for epidermal growth factor.表皮生长因子受体的特性
Cell. 1984 Jun;37(2):357-8. doi: 10.1016/0092-8674(84)90365-9.
3
Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences.表皮生长因子受体与v-erb-B癌基因蛋白序列的高度相似性。
Nature. 1984;307(5951):521-7. doi: 10.1038/307521a0.
4
Adriamycin causes up regulation of epidermal growth factor receptors in actively growing cells.
Exp Cell Res. 1983 Oct;148(1):155-61. doi: 10.1016/0014-4827(83)90195-7.
5
Identity of human epidermal growth factor (EGF) receptor with glycoprotein SA-7: evidence for differential phosphorylation of the two components of the EGF receptor from A431 cells.人表皮生长因子（EGF）受体与糖蛋白SA-7的同一性：来自A431细胞的EGF受体两个组分差异磷酸化的证据。
Proc Natl Acad Sci U S A. 1982 Aug;79(16):5026-30. doi: 10.1073/pnas.79.16.5026.
6
Amplification and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells.人A431癌细胞中表皮生长因子受体基因的扩增及表达增强
Science. 1984 Apr 27;224(4647):417-9. doi: 10.1126/science.6200934.
7
Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.变性RNA与转移至硝酸纤维素膜上的小DNA片段的杂交。
Proc Natl Acad Sci U S A. 1980 Sep;77(9):5201-5. doi: 10.1073/pnas.77.9.5201.
8
Cytogenetic alterations associated with the acquisition of doxorubicin resistance: possible significance of chromosome 7 alterations.与阿霉素耐药性获得相关的细胞遗传学改变：7号染色体改变的可能意义。
Cancer Res. 1987 Dec 15;47(24 Pt 1):6646-52.
9
Location of genes involved in invasion and metastasis on human chromosome 7.
Cancer Res. 1987 Dec 15;47(24 Pt 1):6666-70.
10
Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing.表皮生长因子受体的ATP结合位点处的点突变可消除蛋白酪氨酸激酶活性并改变细胞转运。
Cell. 1987 Oct 23;51(2):199-209. doi: 10.1016/0092-8674(87)90147-4.