Modig J, Busch C, Waernbaum G
Clin Orthop Relat Res. 1975 Nov-Dec(113):187-97. doi: 10.1097/00003086-197511000-00030.
In 4 dogs injected intravenously (i.v.) with 125I labeled fibrinogen, 51Cr labeled platelets and 99mTc labeled albumin, and subjected to successively increasing amounts of i.v. infused monomethylmethacrylate, doses corresponding to the amounts released into the blood stream following implantation of acrylic cement during total hip replacements did not affect the clotting mechanism, did not cause trapping of platelets and fibrin in the lungs, did not generate fat emboli, and did not cause depression of the arterial oxygen tension or blood pressure. Monomethylmethacrylate in whole blood was associated with both blood cells and plasma.
对4只狗静脉注射125I标记的纤维蛋白原、51Cr标记的血小板和99mTc标记的白蛋白，然后静脉输注逐渐增加剂量的甲基丙烯酸甲酯，这些剂量相当于全髋关节置换术中植入骨水泥后释放到血流中的量。结果显示，该剂量不影响凝血机制，不会导致血小板和纤维蛋白在肺部滞留，不会产生脂肪栓子，也不会引起动脉血氧张力或血压降低。全血中的甲基丙烯酸甲酯与血细胞和血浆均有关联。
