Nagasue N, Kanashima R, Kobayashi M, Inokuchi K
Surg Gynecol Obstet. 1979 Aug;149(2):173-6.
The effects of systemic infusion of purified beta glucuronidase, lactic acid and a combination of these were studied in normal dogs from the viewpoints of hemodynamics and blood coagulation. In none of the groups was an obvious deterioration in arterial blood pressure, pulse rate, central venous pressure, portal venous pressure and electrocardiogram observed after the infusions. On the other hand, beta glucuronidase infusion with preceding acidosis caused substantial thrombocytopenia accompanied by a decrease in fibrinogen levels and abnormal thromboelastogram. A similar trend was found by the infusion of beta glucuronidase only. An intermediate abnormality was found by the infusion of lactic acid alone. Histologically, fibrin clots in the pulmonary arteries were often observed in the dogs of all groups, but the quantitative difference among the groups was difficult to evaluate. In the present investigation, shock could not be produced, but other data seemed to indicate that increased levels of acid hydrolases in the blood are concerned with deterioration and irreversibility of shock, especially in an acidotic condition.
从血流动力学和血液凝固的角度，在正常犬中研究了全身输注纯化的β-葡萄糖醛酸酶、乳酸以及二者组合的效果。输注后，所有组均未观察到动脉血压、脉搏率、中心静脉压、门静脉压和心电图有明显恶化。另一方面，在酸中毒之前输注β-葡萄糖醛酸酶会导致严重的血小板减少，并伴有纤维蛋白原水平降低和血栓弹力图异常。仅输注β-葡萄糖醛酸酶也发现了类似趋势。单独输注乳酸则出现中度异常。组织学上，在所有组的犬中均经常观察到肺动脉中的纤维蛋白凝块，但各组之间的定量差异难以评估。在本研究中，未能引发休克，但其他数据似乎表明，血液中酸性水解酶水平升高与休克的恶化和不可逆性有关，尤其是在酸中毒情况下。
