Simons L A, Williams P F
Clin Chim Acta. 1975 Jun 20;61(3):341-52. doi: 10.1016/0009-8981(75)90424-6.
The biochemical composition of lipoproteins in Type V hyperlipoproteinaemia was investigated with special reference to apolipoprotein-B. The in vivo metabolism of protein-labelled low density lipoprotein was also studied in five such patients (3 diabetic, 2 obese subjects). In association with pathologically elevated plasma levels of chylomicrons and very low density lipoproteins, low density lipoprotein concentration was significantly reduced. The proportions of triglyceride to apo-B and triglyceride to cholesterol were significantly increased in all lipoprotein classes, while the proportion of cholesterol to apo-B was significantly reduced. Disappearance of chylomicronaemia with treatment was associated with a prompt increase in low density lipoprotein concentration. The reduced low density lipoprotein concentration was accompanied by an accelerated fractional turnover rate, and by an absolute turnover rate which was subnormal. These results were interpreted as reduced synthesis of low density lipoprotein apoprotein and as a possible block in the conversion of very low density lipoprotein to low density lipoprotein in some Type V patients.
对V型高脂蛋白血症患者脂蛋白的生化组成进行了研究，特别关注载脂蛋白B。还对5例此类患者（3例糖尿病患者，2例肥胖受试者）进行了蛋白质标记的低密度脂蛋白的体内代谢研究。与乳糜微粒和极低密度脂蛋白的血浆水平病理性升高相关，低密度脂蛋白浓度显著降低。所有脂蛋白类中甘油三酯与载脂蛋白B的比例以及甘油三酯与胆固醇的比例均显著增加，而胆固醇与载脂蛋白B的比例则显著降低。治疗后乳糜微粒血症消失与低密度脂蛋白浓度迅速升高有关。低密度脂蛋白浓度降低伴随着分数周转率加快，以及绝对周转率低于正常水平。这些结果被解释为低密度脂蛋白载脂蛋白合成减少，以及在一些V型患者中极低密度脂蛋白向低密度脂蛋白转化可能存在阻滞。
