Ballantyne D, Olsson A G, Carlson L A
Atherosclerosis. 1978 May;30(1):79-87. doi: 10.1016/0021-9150(78)90154-5.
In a detailed study the acute effect of diet and hospital admission on the plasma and lipoprotein lipid concentrations and composition was studied in 28 patients with type IV hyperlipoproteinaemia. Within 6 days there were significant falls in the mean serum cholesterol and triglycerides, very low density lipoprotein (VLDL) cholesterol and triglycerides and in high density lipoprotein triglycerides. These changes were accompanied by a significant rise in the mean low density lipoprotein (LDL) cholesterol concentrations. Using multiple regession models highly significant predictions of the change in VLDL triglyceride (R2 = 0.71) and LDL cholesterol (R2 = 0.47) were obtained utilising the pre-treatment lipoprotein levels as independant variables. Since elevated LDL cholesterol concentations are associated with atherosclerotic disease such models may have important therapeutic applications.
在一项详细研究中，对28例IV型高脂蛋白血症患者的饮食和入院情况对血浆及脂蛋白脂质浓度和组成的急性影响进行了研究。在6天内，平均血清胆固醇、甘油三酯、极低密度脂蛋白（VLDL）胆固醇和甘油三酯以及高密度脂蛋白甘油三酯均显著下降。这些变化伴随着平均低密度脂蛋白（LDL）胆固醇浓度的显著升高。利用多元回归模型，以治疗前脂蛋白水平作为自变量，对VLDL甘油三酯（R2 = 0.71）和LDL胆固醇（R2 = 0.47）的变化获得了高度显著的预测。由于升高的LDL胆固醇浓度与动脉粥样硬化疾病相关，此类模型可能具有重要的治疗应用价值。
