Gregoriou O, Vitoratos N, Papadias C, Konidaris S, Maragudakis A, Zourlas P A
Second Department of Obstetrics and Gynecology, University of Athens, Areteion Hospital, Greece.
Int J Gynaecol Obstet. 1991 Jun;35(2):151-6. doi: 10.1016/0020-7292(91)90819-q.
Twenty-four women with infertility caused by antisperm antibodies were treated by homologous intrauterine insemination. Initially, all the women had timed intrauterine insemination by washed spermatozoa for three cycles. The pregnancy rate per couple was 4.20%. The remaining 23 patients received a combined treatment of chlomiphene citrate and intrauterine insemination for three cycles, which did not increase the pregnancy rate per couple and per cycle (4.3% and 1.4% respectively). Thereafter, the remaining 22 patients received a combined treatment of hMG and intrauterine insemination for another three cycles which resulted in a pregnancy rate per cycle (6.1%) and per couple (18.20%) that was significantly greater (P less than 0.01). We conclude that infertile women with antisperm antibodies can benefit after a trial of induction of multiple follicular development with hMG in combination with intrauterine insemination.
24例因抗精子抗体导致不孕的女性接受了同种宫内授精治疗。起初，所有女性均采用洗涤精子进行定时宫内授精，共三个周期。每对夫妇的妊娠率为4.20%。其余23例患者接受了枸橼酸氯米芬与宫内授精联合治疗三个周期，这并未提高每对夫妇和每个周期的妊娠率（分别为4.3%和1.4%）。此后，其余22例患者接受了人绝经期促性腺激素（hMG）与宫内授精联合治疗另外三个周期，这使得每个周期的妊娠率（6.1%）和每对夫妇的妊娠率（18.20%）显著提高（P<0.01）。我们得出结论，抗精子抗体所致不孕的女性在尝试使用hMG诱导多个卵泡发育并联合宫内授精后可能会受益。
