Margalloth E J, Sauter E, Bronson R A, Rosenfeld D L, Scholl G M, Cooper G W
Department of Obstetrics and Gynecology, North Shore University Hospital, Cornell University Medical College, Manhasset, New York 11030.
Fertil Steril. 1988 Sep;50(3):441-6. doi: 10.1016/s0015-0282(16)60129-2.
Ninety-one women with long-standing infertility in the presence of humoral antisperm antibodies (ASA) underwent 473 cycles of intrauterine insemination of washed sperm (IUI), resulting in 26 pregnancies. Nine pregnancies were achieved in 67 women who underwent 285 IUI during unstimulated cycles (13% pregnancy rate; 3% pregnancy/cycles of treatment). Twenty women underwent 86 IUI after clomiphene citrate (CC) stimulation, resulting in 6 pregnancies (30%; 7% per cycle), while 28 underwent 102 cycles of IUI after human menopausal gonadotropins (hMG) stimulation, resulting in 11 pregnancies (39%; 11% per cycle). Twenty-one of the 26 pregnancies (81%) were achieved in the first 2 IUI cycles. During unstimulated and CC IUI cycles, all pregnancies occurred in the first two cycles of treatment, while with hMG stimulation pregnancies also occurred in the third, fourth, and fifth IUI cycles. Nine of these 91 women subsequently conceived spontaneously, and three others conceived through in vitro fertilization. Only 6 of the 38 pregnancies resulted in spontaneous abortion (16%). Thus, pregnancies achieved in women with ASA have no increased risk of abortion.
91名存在体液抗精子抗体（ASA）且长期不孕的女性接受了473个周期的洗涤精子宫腔内人工授精（IUI），共产生26例妊娠。67名女性在未刺激周期接受了285个周期的IUI，其中9例妊娠（妊娠率13%；每治疗周期妊娠率3%）。20名女性在枸橼酸氯米芬（CC）刺激后接受了86个周期的IUI，产生6例妊娠（30%；每周期7%），而28名女性在人绝经期促性腺激素（hMG）刺激后接受了102个周期的IUI，产生11例妊娠（39%；每周期11%）。26例妊娠中有21例（81%）在最初2个IUI周期内实现。在未刺激和CC-IUI周期中，所有妊娠均发生在治疗的前两个周期，而在hMG刺激下，妊娠也发生在第3、第4和第5个IUI周期。这91名女性中有9名随后自然受孕，另有3名通过体外受精受孕。38例妊娠中只有6例自然流产（16%）。因此，ASA女性实现的妊娠流产风险没有增加。
