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西多福韦（CDV）的烷氧基烷基酯、环化CDV和（S）-9-（3-羟基-2-膦酰甲氧基丙基）腺嘌呤在细胞单层和器官型培养物中对正痘病毒的活性。

Activities of alkoxyalkyl esters of cidofovir (CDV), cyclic CDV, and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine against orthopoxviruses in cell monolayers and in organotypic cultures.

作者信息

Lebeau Ilya, Andrei Graciela, Dal Pozzo Fabiana, Beadle James R, Hostetler Karl Y, De Clercq Erik, van den Oord Joost, Snoeck Robert

机构信息

Rega Institute for Medical Research, K.U. Leuven, Minderbroedersstraat 10, Leuven, Belgium.

出版信息

Antimicrob Agents Chemother. 2006 Jul;50(7):2525-9. doi: 10.1128/AAC.01489-05.

DOI:10.1128/AAC.01489-05
PMID:16801436
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1489770/
Abstract

The potencies of several alkoxyalkyl esters of acyclic nucleoside phosphonates against vaccinia virus and cowpox virus were evaluated in cell monolayers and three-dimensional epithelial raft cultures. Prodrugs were at least 20-fold more active than their parent compounds. Octadecycloxyethyl-(S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine emerged as the most potent derivative.

摘要

在细胞单层和三维上皮筏培养物中评估了几种无环核苷膦酸酯的烷氧基烷基酯对痘苗病毒和牛痘病毒的效力。前药的活性比其母体化合物至少高20倍。十八烷氧基乙基-(S)-9-(3-羟基-2-膦酰基甲氧基丙基)腺嘌呤是最有效的衍生物。

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Antimicrob Agents Chemother. 2005 Dec;49(12):4843-52. doi: 10.1128/AAC.49.12.4843-4852.2005.
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Organotypic epithelial raft cultures as a model for evaluating compounds against alphaherpesviruses.器官型上皮筏培养作为评估抗甲型疱疹病毒化合物的模型。
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Ether lipid-ester prodrugs of acyclic nucleoside phosphonates: activity against adenovirus replication in vitro.无环核苷膦酸酯的醚脂质酯前药：体外抗腺病毒复制活性
J Infect Dis. 2005 Feb 1;191(3):396-9. doi: 10.1086/426831. Epub 2004 Dec 29.
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