大鼠经氟碳代血液（氟索-DA）或生理盐水进行中度血液稀释后的血浆容量、血容量及血浆蛋白浓度
Plasma volumes, blood volumes, and plasma protein concentrations after moderate haemodilution with fluosol-DA or normal saline in the rat.
作者信息
Shrewsbury R P
机构信息
Division of Pharmaceutics, School of Pharmacy, University of North Carolina, Chapel Hill 27599-7360.
出版信息
J Pharm Pharmacol. 1991 May;43(5):371-4. doi: 10.1111/j.2042-7158.1991.tb06709.x.
Plasma volumes, blood volumes, and plasma total protein, albumin, and bilirubin concentrations have been determined in rats for 72 h following 20 or 40 mL kg-1 haemodilution with Fluosol-DA or 0.9% NaCl. Haemodilution with 20 mL kg-1 of either haemodiluent had no influence on the measured values. Plasma and blood volumes did not change after Fluosol-DA haemodilution at 40 mL kg-1, but albumin and bilirubin concentrations were decreased for 72 h. Only bilirubin concentrations were decreased for 72 h following haemodilution with 40 mL kg-1 of 0.9% NaCl. It was concluded that changes in a drug's plasma protein binding, and not the plasma or blood volume, are responsible for the reported alterations in a drug's apparent volume of distribution after haemodilution.
在用氟碳乳剂（Fluosol - DA）或0.9%氯化钠溶液以20或40 mL kg-1进行血液稀释后的72小时内，测定了大鼠的血浆容量、血容量以及血浆总蛋白、白蛋白和胆红素浓度。用20 mL kg-1的任何一种稀释剂进行血液稀释对测量值均无影响。以40 mL kg-1的氟碳乳剂进行血液稀释后，血浆和血容量没有变化，但白蛋白和胆红素浓度在72小时内降低。用40 mL kg-1的0.9%氯化钠溶液进行血液稀释后，仅胆红素浓度在72小时内降低。得出的结论是，药物血浆蛋白结合的变化而非血浆或血容量的变化，是血液稀释后药物表观分布容积发生报道改变的原因。
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