治疗发作性睡病中嗜睡症状的药物相对疗效
Relative efficacy of drugs for the treatment of sleepiness in narcolepsy.
作者信息
Mitler M M, Hajdukovic R
机构信息
Scripps Clinic and Research Foundation, La Jolla, California 92037.
出版信息
Sleep. 1991 Jun;14(3):218-20. doi: 10.1093/sleep/14.3.218.
Abstract
A survey was conducted on 10 polysomnographic studies on the pharmacologic treatment of the sleepiness of narcolepsy. Three studies employed the MSLT and 7 employed the MWT as their polygraphic measure of sleep tendency. Statistically and clinically significant therapeutic changes were apparent for pemoline, modafinil, dextroamphetamine and methylphenidate. Codeine, ritanserin and protriptyline did show statistically significant effects. The common feature among the drugs that did produce clinically significant improvements seems to be facilitatory action on central catecholaminergic transmission. Within this group of drugs, only methylphenidate and dextroamphetamine brought MWT sleep latencies to approximately 70% of normal levels.
摘要
对10项关于发作性睡病嗜睡症药物治疗的多导睡眠图研究进行了调查。3项研究采用了多次睡眠潜伏期试验（MSLT），7项研究采用了多次觉醒试验（MWT）作为其睡眠倾向的多导记录测量方法。匹莫林、莫达非尼、右旋苯丙胺和哌甲酯在统计学和临床上均有显著的治疗效果。可待因、利坦色林和普罗替林确实显示出统计学上的显著效果。产生临床上显著改善的药物的共同特征似乎是对中枢儿茶酚胺能传递的促进作用。在这组药物中，只有哌甲酯和右旋苯丙胺使多次觉醒试验的睡眠潜伏期达到正常水平的约70%。
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