Segawa K, Mabuchi C, Shiozawa Z, Nakazawa S
Gastroenterol Jpn. 1977;12(1):1-6. doi: 10.1007/BF02773995.
In 10 peptic ulcer patients, 5 duodenal ulcer and 5 gastric ulcer patients, the relation of nocturnal intragastric pH to EEG sleep stages was examined. The nocturnal intragastric pH was monitored by pH-measuring telemeter and sleep stages were recorded simultaneously by electroencephalography throughout the night. The EEG sleep stages were classified after the criteria of Dement and Kleitman. The average of intragastric pH level at each sleep stage was higher in gastric ulcer than the duodenal ulcer. The intragastric pH level became low as the patients' sleep advanced to deep stage. This tendency was more likely in duodenal ulcer patients than the gastric ulcer patients, which indicated that the cephalic phase might play an important role in the pathogenesis of hyperacidity in duodenal ulcer.
在10例消化性溃疡患者中，5例十二指肠溃疡患者和5例胃溃疡患者，研究了夜间胃内pH值与脑电图睡眠阶段的关系。通过pH测量遥测仪监测夜间胃内pH值，并通过脑电图在整个夜间同时记录睡眠阶段。根据德门特和克莱特曼的标准对脑电图睡眠阶段进行分类。胃溃疡患者在每个睡眠阶段的胃内pH值平均水平高于十二指肠溃疡患者。随着患者睡眠进入深度阶段，胃内pH值水平降低。十二指肠溃疡患者比胃溃疡患者更易出现这种趋势，这表明头期可能在十二指肠溃疡胃酸过多的发病机制中起重要作用。
