Watanabe M, Nakazawa S, Yoshino J, Yamao K, Inui K, Yamachika H, Kanemaki N, Wakabayashi T, Fujimoto M, Watarai K
Department of Internal Medicine, Second Theaching Hospital, Fujita Health University School of Medicine.
Nihon Shokakibyo Gakkai Zasshi. 1995 Sep;92(9):1241-9.
We studied the correlation of the gastric acid secretion and the depth of sleep at night with no medication in 32 cases (19 gastric ulcer, 6 duodenal ulcer patients and 7 healthy controls). Using Memory PH: Monitor intragastric pH values were consecutively measured without antiulcer drugs. The depth of sleep were monitored continuously by recording without any sleeping drugs. In healthy controls, the pH values of awake phase was significantly lower than that of sleep stage 1, 4 and rapid eye movement (REM) phases. The pH values of REM phases were significantly high rather than that of sleep stage 1 and 2 phases. In patients with gastric ulcer, the pH values of awake phases were significantly lower than that of sleep stage 1 and REM phases. The pH values of REM phases were significantly high rather than that of the other sleep stages. On the other hand, in patients with duodenal ulcer, the obvious changes of the pH values were not seen with sleep stages. The pH values of healthy controls and gastric patients were changed with sleep stages. But the pH of duodenal ulcer patients were not changed obviously. Therefore, it is suggested that the dysfunction of autonomous nervous system was influenced the nocturnal intragastric pH in the patients with duodenal ulcer and played one of the important role in the occurrence of duodenal ulcer.
我们对32例患者（19例胃溃疡患者、6例十二指肠溃疡患者和7例健康对照者）在未用药情况下的胃酸分泌与夜间睡眠深度的相关性进行了研究。使用记忆式pH计：在未使用抗溃疡药物的情况下连续测量胃内pH值。通过记录在未使用任何助眠药物的情况下持续监测睡眠深度。在健康对照者中，清醒期的pH值显著低于睡眠第1阶段、第4阶段和快速眼动（REM）阶段。REM阶段的pH值显著高于睡眠第1阶段和第2阶段。在胃溃疡患者中，清醒期的pH值显著低于睡眠第1阶段和REM阶段。REM阶段的pH值显著高于其他睡眠阶段。另一方面，在十二指肠溃疡患者中，未观察到pH值随睡眠阶段出现明显变化。健康对照者和胃溃疡患者的pH值随睡眠阶段而变化。但十二指肠溃疡患者的pH值未明显改变。因此，提示自主神经系统功能障碍影响十二指肠溃疡患者夜间胃内pH值，在十二指肠溃疡的发生中起重要作用之一。
