Cottet V, Pariente A, Nalet B, Lafon J, Milan C, Olschwang S, Faivre J, Bonaiti-Pellié C, Bonithon-Kopp C
INSERM E 106, Faculté de Médecine, Dijon, France.
Aliment Pharmacol Ther. 2006 Jul 1;24(1):101-9. doi: 10.1111/j.1365-2036.2006.02966.x.
Little is known about compliance with colonoscopy as a screening method in first-degree relatives of patients with large adenomas. Aims To evaluate the compliance with screening colonoscopy among this population, and its determinants.
Data were obtained from the family part of the GEADE study, a study on genetic factors of colorectal adenomas. Index cases were 306 patients with adenomas > or = 10 mm. All living first-degree relatives aged 40-75 who could be contacted by the index case were asked to undergo a colonoscopy, unless they had had one in the previous 5 years.
Among 674 eligible relatives, 56 had had a colonoscopy within the preceding 5 years and 114 underwent a screening colonoscopy resulting in a compliance with screening colonoscopy of 18%. This was not related to most characteristics of index cases. Compliance was significantly lower when the index case lived in the Greater Paris area than when he/she lived in other areas (12% vs. 21%). It was higher in siblings (18%) and offspring (23%) than in parents (9%) and in relatives under 55 years old (22%) than in relatives aged 55 and over (15%).
Compliance with colonoscopy was low in first-degree relatives of patients with large adenomas. The reasons for this should be determined and appropriate strategies developed to increase compliance.
关于在患有大腺瘤患者的一级亲属中结肠镜检查作为一种筛查方法的依从性知之甚少。目的评估该人群中筛查结肠镜检查的依从性及其决定因素。
数据来自GEADE研究的家庭部分，这是一项关于结直肠腺瘤遗传因素的研究。索引病例为306例腺瘤直径≥10毫米的患者。所有年龄在40 - 75岁、能被索引病例联系到的在世一级亲属均被要求接受结肠镜检查，除非他们在过去5年内已做过。
在674名符合条件的亲属中，56人在过去5年内已做过结肠镜检查，114人接受了筛查结肠镜检查，筛查结肠镜检查的依从率为18%。这与索引病例的大多数特征无关。当索引病例居住在大巴黎地区时，依从率显著低于其居住在其他地区时（12%对21%）。兄弟姐妹（18%）和后代（23%）的依从率高于父母（9%），55岁以下亲属（22%）的依从率高于55岁及以上亲属（15%）。
患有大腺瘤患者的一级亲属中结肠镜检查的依从性较低。应确定其原因并制定适当策略以提高依从性。
