特发性突发性感音神经性听力损失的治疗
Treatment of idiopathic sudden sensorineural hearing loss.
作者信息
Jeyakumar Anita, Francis David, Doerr Timothy
机构信息
Department of Otolaryngology, University of Rochester, Strong Memorial Hospital, Rochester, NY 14624, USA.
出版信息
Acta Otolaryngol. 2006 Jul;126(7):708-13. doi: 10.1080/00016480500504234.
CONCLUSION
The therapeutic role of corticosteroids and/or corticosteroids with antiviral agents for sudden sensorineural hearing loss (SSNHL) has yet to be fully elucidated; however, in cases where deafness is profound and of recent onset, a therapeutic trial is indicated.
OBJECTIVES
To investigate treatment regimens and their efficacies, as well as evaluating the potential prognostic correlates and allowing comparison between local and national standards of care for SSNHL.
PATIENTS AND METHODS
A retrospective evidence-based case series of 143 patients seen at the University of Rochester, Department of Otolaryngology between 1999 and 2002 was investigated. Treatment modalities included (1) observation, (2) steroids, and (3) steroids with antivirals.
RESULTS
The study demonstrates that steroid treatment, alone or in combination with antivirals, results in a significant improvement rate compared with observation. Results indicate that the more expediently a patient with SSNHL is seen by an otolaryngologist, the better their prognosis.
结论
皮质类固醇和/或皮质类固醇与抗病毒药物对突发性感音神经性听力损失（SSNHL）的治疗作用尚未完全阐明；然而，在耳聋严重且为近期发病的情况下，建议进行治疗试验。
目的
研究治疗方案及其疗效，评估潜在的预后相关因素，并比较SSNHL的地方和国家标准治疗。
患者与方法
对1999年至2002年在罗切斯特大学耳鼻喉科就诊的143例患者进行回顾性循证病例系列研究。治疗方式包括：（1）观察；（2）类固醇；（3）类固醇与抗病毒药物联合使用。
结果
研究表明，与观察相比，单独使用类固醇治疗或与抗病毒药物联合使用类固醇治疗的改善率显著。结果表明，SSNHL患者由耳鼻喉科医生诊治的速度越快，其预后越好。
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