Zdanov Stephanie, Remacle Jose, Toussaint Olivier
Unit of Cellular Biochemistry and Biology, the University of Namur, Belgium.
Ann N Y Acad Sci. 2006 May;1067:210-6. doi: 10.1196/annals.1354.025.
Premature senescence of human fibroblasts is established after exposure to an acute sublethal concentration of H(2)O(2). Overexpression of transforming growth factor-beta1 (TGF-beta1) was shown to be responsible for the appearance of the biomarkers of senescence in these conditions. Other studies have shown that incubation of human fibroblasts with TGF-beta1 leads to overexpression of H(2)O(2). In this work, we show an increased production of H(2)O(2) by human fibroblasts as premature senescence is established after an initial exposure to H(2)O(2).
人类成纤维细胞在暴露于急性亚致死浓度的H₂O₂后会出现早衰。研究表明，在这些条件下，转化生长因子β1（TGF-β1）的过表达是导致衰老生物标志物出现的原因。其他研究表明，将人类成纤维细胞与TGF-β1一起孵育会导致H₂O₂的过表达。在这项研究中，我们发现，人类成纤维细胞在初次暴露于H₂O₂后建立早衰时，H₂O₂的产生会增加。
