Machida Shuichi, Narusawa Mitsuo
Department of Physical Education, International Budo University, Chiba, Japan.
Ann N Y Acad Sci. 2006 May;1067:349-53. doi: 10.1196/annals.1354.049.
Sarcopenia is the involuntary loss of skeletal muscle mass and strength that occurs with aging, resulting in physical frailty. One potential explanation for sarcopenia is the failure of muscle to regenerate after damage, some of which may be due to changes in the function of satellite cells. Recent studies have identified novel populations of adult stem cells in skeletal muscle, such as hematopoietic stem cells. To understand the cellular mechanisms of sarcopenia, we examined the expression of satellite cells and hematopoietic stem cells in old regenerating muscles based on the expression profiles of several markers related to those cells.
肌肉减少症是指随着年龄增长而出现的骨骼肌质量和力量的非自愿性丧失，会导致身体虚弱。肌肉减少症的一种潜在解释是肌肉在受损后无法再生，其中一些可能归因于卫星细胞功能的变化。最近的研究在骨骼肌中发现了新的成体干细胞群体，如造血干细胞。为了了解肌肉减少症的细胞机制，我们根据与这些细胞相关的几种标志物的表达谱，研究了老年再生肌肉中卫星细胞和造血干细胞的表达情况。
