Lloyd D A J, Gabe S M, Windsor A C J
The Lennard-Jones Intestinal Failure Unit, St Mark's Hospital and Academic Institute, Harrow, UK.
Br J Surg. 2006 Sep;93(9):1045-55. doi: 10.1002/bjs.5396.
The management of enterocutaneous fistula is challenging, with significant associated morbidity and mortality. This article reviews treatment, with emphasis on the provision and optimal route of nutritional support.
Relevant articles were identified using Medline searches. Secondary articles were identified from the reference lists of key papers.
Management of enterocutaneous fistula should initially concentrate on correction of fluid and electrolyte imbalances, drainage of collections, treatment of sepsis and control of fistula output. The routine use of somatostatin infusion and somatostatin analogues remains controversial; although there are data suggesting reduced time to fistula closure, there is little evidence of increased probability of spontaneous closure. Malnutrition is common and adequate nutritional provision is essential, enteral where possible, although supplemental parenteral nutrition is often required for high-output small bowel fistulas. The role of immunonutrition is unknown. Surgical repair should be attempted when spontaneous fistula closure does not occur, but it should be delayed for at least 3 months.
肠皮肤瘘的管理具有挑战性,伴有显著的相关发病率和死亡率。本文回顾了治疗方法,重点是营养支持的提供和最佳途径。
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肠皮肤瘘的管理应首先集中于纠正液体和电解质失衡、引流积液、治疗脓毒症以及控制瘘管排出量。常规使用生长抑素输注和生长抑素类似物仍存在争议;尽管有数据表明瘘管闭合时间缩短,但几乎没有证据表明自发闭合的可能性增加。营养不良很常见,提供充足的营养至关重要,尽可能采用肠内营养,尽管高流量小肠瘘通常需要补充肠外营养。免疫营养的作用尚不清楚。当瘘管不能自发闭合时应尝试手术修复,但应至少延迟3个月。