Teubner A, Morrison K, Ravishankar H R, Anderson I D, Scott N A, Carlson G L
Intestinal Failure Unit, Department of Surgery, Hope Hospital, Salford, UK.
Br J Surg. 2004 May;91(5):625-31. doi: 10.1002/bjs.4520.
Use of total parenteral nutrition (TPN) in patients with acute intestinal failure due to enteric fistulation might be avoided if a simpler means of nutritional support was available. The aim of this study was to determine whether feeding via an intestinal fistula (fistuloclysis) would obviate the need for TPN.
Fistuloclysis was attempted in 12 patients with jejunocutaneous or ileocutaneous fistulas with mucocutaneous continuity. Feeding was achieved by inserting a gastrostomy feeding tube into the intestine distal to the fistula. Infusion of enteral feed was increased in a stepwise manner, without reinfusion of chyme, until predicted nutritional requirements could be met by a combination of fistuloclysis and regular diet, following which TPN was withdrawn. Energy requirements and nutritional status were assessed before starting fistuloclysis and at the time of reconstructive surgery.
Fistuloclysis replaced TPN entirely in 11 of 12 patients. Nutritional status was maintained for a median of 155 (range 19-422) days until reconstructive surgery could be safely undertaken in nine patients. Two patients who did not undergo surgery remained nutritionally stable over at least 9 months. TPN had to be recommenced in one patient. There were no complications associated with fistuloclysis.
Fistuloclysis appears to provide effective nutritional support in selected patients with enterocutaneous fistula.
如果有更简单的营养支持方法,因肠瘘导致急性肠衰竭的患者可能无需使用全胃肠外营养(TPN)。本研究的目的是确定经肠瘘喂养(瘘管滴注法)是否可避免使用TPN。
对12例空肠造口或回肠造口且黏膜皮肤连续的患者尝试瘘管滴注法。通过将胃造口喂养管插入瘘管远端的肠道来实现喂养。肠内营养输注逐步增加,不回输食糜,直至瘘管滴注法和常规饮食相结合能够满足预计的营养需求,之后停用TPN。在开始瘘管滴注法之前以及重建手术时评估能量需求和营养状况。
12例患者中有11例完全用瘘管滴注法替代了TPN。9例患者在中位时间155天(范围19 - 422天)内维持营养状况,直至能够安全进行重建手术。2例未接受手术的患者至少9个月内营养状况保持稳定。1例患者不得不重新开始使用TPN。瘘管滴注法未出现并发症。
瘘管滴注法似乎能为部分肠造口瘘患者提供有效的营养支持。